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Measuring Accuracy in Digital Pathology Ole Eichhorn Chief Technology Officer, Aperio ole@aperio.com FDA panel discussio

Measuring Accuracy in Digital Pathology Ole Eichhorn Chief Technology Officer, Aperio ole@aperio.com FDA panel discussion, Oct 22-23, 2009. Measuring Accuracy in Digital Pathology. ?. ?. ?. ?. Develop Method to Compare Diagnoses. Develop Method to Record Diagnoses. ?.

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Measuring Accuracy in Digital Pathology Ole Eichhorn Chief Technology Officer, Aperio ole@aperio.com FDA panel discussio

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  1. Measuring Accuracy inDigital PathologyOle EichhornChief Technology Officer, Aperioole@aperio.comFDA panel discussion, Oct 22-23, 2009

  2. Measuring Accuracy in Digital Pathology ? ? ? ? Develop Method to Compare Diagnoses Develop Method to Record Diagnoses ? Record Diagnoses, Truth, Compare for Accuracy Develop Method to Determine Ground Truth

  3. Method to Record Diagnoses Pathology reports are complex: English text with medical terms Different reports may correspond to same diagnosis Nuances in reports vary by lab, by region, by training, by age, etc.

  4. Method to Record Diagnoses Record diagnoses in structured way Tissue- and preparation- specific Use corresponding CAP* checklist for Primary Diagnosis (most prevalent or most significant finding) Record all Significant Features Cross-check to ensure diagnosis is recorded consistently Can be used for all diagnoses regardless of method (conventional microscopy or digital pathology) * College of American Pathologists

  5. Method to Compare Diagnoses ? • Recorded Diagnosis is a “tree” of choices • Compare two trees, assess severity of each difference • Most severe difference is overall comparison result: ND = no difference, I = incidental, S = significant, CS = clinically significant (affects patient care) ND, I, S, CS

  6. Method to Determine Ground Truth Nature of Pathology • Pathology is inherently subjective • Many cases are “obvious” (most pathologists agree) • Difficult cases are typically diagnosed via consultation Record Ground Truth in structured way • Convene panel of expert pathologists • Diagnose using conventional microscopy • Resolve disagreements using consultation • Record consensus using Method to Record Diagnoses

  7. Process to Measure Accuracy ? ? ? ? • Record Diagnoses • Determine Ground Truth • Compare Diagnoses to Ground Truth Measure Accuracy

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