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Measuring Accuracy in Digital Pathology Ole Eichhorn Chief Technology Officer, Aperio ole@aperio.com FDA panel discussio PowerPoint Presentation
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Measuring Accuracy in Digital Pathology Ole Eichhorn Chief Technology Officer, Aperio ole@aperio.com FDA panel discussion, Oct 22-23, 2009. Measuring Accuracy in Digital Pathology. ?. ?. ?. ?. Develop Method to Compare Diagnoses. Develop Method to Record Diagnoses. ?.

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Measuring Accuracy inDigital PathologyOle EichhornChief Technology Officer, Aperioole@aperio.comFDA panel discussion, Oct 22-23, 2009

measuring accuracy in digital pathology
Measuring Accuracy in Digital Pathology

?

?

?

?

Develop Method to Compare Diagnoses

Develop Method to Record Diagnoses

?

Record Diagnoses, Truth, Compare for Accuracy

Develop Method to Determine Ground Truth

method to record diagnoses
Method to Record Diagnoses

Pathology reports are complex: English text with medical terms

Different reports may correspond to same diagnosis

Nuances in reports vary by lab, by region, by training, by age, etc.

method to record diagnoses1
Method to Record Diagnoses

Record diagnoses in structured way

Tissue- and preparation- specific

Use corresponding CAP* checklist for Primary Diagnosis (most prevalent or most significant finding)

Record all Significant Features

Cross-check to ensure diagnosis is recorded consistently

Can be used for all diagnoses regardless of method (conventional microscopy or digital pathology)

* College of American Pathologists

method to compare diagnoses
Method to Compare Diagnoses

?

  • Recorded Diagnosis is a “tree” of choices
  • Compare two trees, assess severity of each difference
  • Most severe difference is overall comparison result:

ND = no difference, I = incidental, S = significant,

CS = clinically significant (affects patient care)

ND, I, S, CS

method to determine ground truth
Method to Determine Ground Truth

Nature of Pathology

  • Pathology is inherently subjective
  • Many cases are “obvious” (most pathologists agree)
  • Difficult cases are typically diagnosed via consultation

Record Ground Truth in structured way

  • Convene panel of expert pathologists
  • Diagnose using conventional microscopy
  • Resolve disagreements using consultation
  • Record consensus using Method to Record Diagnoses
process to measure accuracy
Process to Measure Accuracy

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?

?

?

  • Record Diagnoses
  • Determine Ground Truth
  • Compare Diagnoses to Ground Truth

Measure Accuracy