Predicting Proton NMR Spectra and Structure Interpreting Techniques
This guide covers the essential skills for predicting proton NMR spectra from chemical structures and interpreting spectra to deduce compound structures. Useful in the synthesis of known targets, the methodology is straightforward and includes practical steps. Key techniques involve identifying the number of signals, utilizing data tables, and drawing spectra. Practice problems using ChemDraw are provided, with an emphasis on common pitfalls, such as avoiding chiral compounds in certain examples. Enhance your NMR skills with practical advice and experience.
Predicting Proton NMR Spectra and Structure Interpreting Techniques
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Presentation Transcript
Same Material, Two Skills • Predicting proton spectra: given a structure, what will the proton NMR look like? • Useful in synthesis of known target • A little more straightforward • Interpreting proton spectra: given a spectrum, what is the structure of compound • Identify an unknown; side products in synthesis • More experience needed
Predicting Spectra • Step 1: Identify number of signals
Predicting Spectra • Step 2: Table of data
Predicting Spectra • Step 3: Draw spectrum
Practice • Make problems for yourself: ChemDraw • Don’t do chiral compounds
6H, d 5H, multiplet 2H, doublet 1H, multiplet
