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Rekombinanta allergen; diagnostik och terapi

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Rekombinanta allergen; diagnostik och terapi. Professor/överläkare Marianne van Hage Enheten för klinisk immunologi och allergi Avd. för klinisk immunologi och transfusionsmedicin Karolinska Institutet och Universitetssjukhuset Stockholm. Advantages with r ecombinant allergens.

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Rekombinanta allergen; diagnostik och terapi

Professor/överläkare Marianne van Hage

Enheten för klinisk immunologi och allergi

Avd. för klinisk immunologi och transfusionsmedicin

Karolinska Institutet och Universitetssjukhuset

Stockholm

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Advantages with recombinant allergens

  • Represent pure molecule
  • Potencies can be exactly adjusted
  • Can be produced in unlimited amounts and with consistent composition
  • Many different recombinant allergens have been cloned, sequenced and expressed
  • Discriminate between cross- and co-sensitisation
  • Better management of the patient
  • Improve selection of patients for allergen-specific immunotherapy
  • New approach for allergen-specific immunotherapy

Fel d 1

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Innehåll

  • Föreläsningen kommer att beskriva vad rekombinanta allergen är. Exempel på nyttan av att diagnosticera med rekombinanta allergen kommer att ges. De första immunterapistudierna med rekombinanta allergen gås igenom. Nya adjuvans och administrationsvägar diskuteras.
  • Kazemi-Shirazia L et al. Recombinant Marker Allergens: Diagnostic Gatekeepers for the Treatment of Allergy. Int Arch Allergy Immunol 2002;127:259-268
  • Vrtala S. From allergen genes to new forms of allergy diagnosis and treatment. Allergy. 2008 Mar;63(3):299-309. Review
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