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Discover the intricate process of meiosis creating gametes, leading to genetic diversity. Learn about key stages, errors, and consequences such as aneuploidy and polyploidy. Explore syndromes like Down syndrome and Turner syndrome.
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Creation of Gametes • Asexual reproduction yields two identical organisms (with exception of mutations) • Sexual reproduction merges the genes of the two parents • Result: two versions of each chromosome • Called homologous chromosomes • Organism is diploid (2n=46) • All somatic cells are diploid
First 22 are autosomes • Chromosome 23 is the sex chromosome • Haploid (n=23) sex cells merge to create a zygote in sexual reproduction • Meiosis creates these sex cells (gametes) • The overall process is the sexual life cycle
Interphase I of Meiosis Homologous chromosomes Chromosomes replicate Homologous chromosomes separate Meiosis I Meiosis II Sister chromatids separate
Interphase I • Similar to mitosis, chromatin replicates • Centrioles replicate, proteins form around to make the centrosomes • Also called the microtubule organizing centre • Collectively, with microtubules, is called mitotic spindle
Prophase I • Longest part of meiosis • Chromatin condenses, chromosomes become visible • Homologous chromosomes come pair up, forming a tetrad – called synapsis • The chromatids can overlap, called a chiasmata • All other features are similar to mitosis
Metaphase I • Almost identical to metaphase in mitosis, with the tetrad exception
Anaphase I • Sister chromatids remain attached, tetrads separate (cells are now haploid) • This is the independent assortment mentioned previously
Telophase I • Homologous chromosomes are at opposite poles of cell • Each end is now haploid • Cytokinesis takes place simultaneously • Some cells proceed to interphase II, others directly to prophase II • No cells replicate chromatin again
Prophase II • Spindle forms again, chromosomes move towards equator
Metaphase II • Closely resembling mitosis, metaphase plate is formed
Anaphase II • Sister chromatids finally separate
Telophase II • Mitotic spindle breaks down, nucleus reforms around two daughter nuclei
Errors • Some of the processes can go awry • If anaphase I or II does not proceed correctly, the chromosomes may not be shared evenly • This is called nondisjunction • More of a problem if it occurs during meiosis I • Can take place in mitosis, but not as much of a concern
An abnormal chromosome number is called aneuploidy • If faulty gamete succeeds in fertilization, the offspring with have health consequences • If a gamate with an extra chromosome fertilizes, the zygote is trisomic (2n+1) • If the gamete has a chromosome missing, the zygote is monosomic (2n-1) • Ex. Extra chromosome 21 – Down syndrome
If the extra chromosome is an X in a male (XXY), called Klinefelter syndrome • The individual will have male sex organs, but the testes will be abnormally small, and he will be sterile • As well, femine characteristics such as breast enlargement is common
Final example is Turner syndrome • Example of monosomyX • Individuals are classified X0, and are female • However, sex organs do not mature at adolescence and secondary sex characteristics fail to develop
Polyploidy • Also possible for anaphase I or II to completely fail and all chromosomes move to one cell • Referred to as polyploidy • Could have three chromosome sets (triploidy, 3n) or four (tetraploidy, 4n)