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U05-23088

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  1. U05-23088

  2. 19 yo African female student (here since 2001) Medical exam for Immigrationnotable for protein-uria and Hematuria. Serum Creatinine 81umol/L (88 Aug 5)No h/o UTI's or Pyelo.Headaches....Advil over 5 monthsIntermittent swellings lower ExtremityNonsmoker social EtohInduced Aborton. Single partner (Sero -ve)24 hour urine 5.6gmsNegative Sero( ANA,C3,C,Hepatitis).Normal U/sLeft lower pole Bx

  3. IF • IgG- Negative • IgA- Moderate to strong mesangial staining • IgM- Mild mesangial staining • C3- Mild to moderate mesangial staining • C1q- Negative • Kappa- Mild mesangial staining • Lambda- Mild to moderate mesangial staining • Fibrin- Mild mesangial staining • Albumin- Negative

  4. IgA

  5. IgM

  6. C3

  7. Kappa

  8. Lambda

  9. Fibrin

  10. Diagnosis:Renal Biopsy:IgA Nephropathy with proliferative and necrotizing lesions including crescent formation