Lyme Disease and The Lyme Disease Vaccine. Presentation By Jason Hadrath. Characterized by inflammation of:. 1. connective tissue (skin and joints). 2. nervous tissue. 3. cardiac tissue. What is Lyme Disease?. A multisystem inflammatory disease.
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1. connective tissue (skin and joints)
2. nervous tissue
3. cardiac tissueWhat is Lyme Disease?
BEST POINT FOR TREATMENT !!
40 % of lyme cases are asymptomatic in the early stages.
Ixodes pacificusMore Ticks
Developed by SmithKline Beecham Biologicals.
Given in three doses. Two doses, one month apart and again in 12 months.
Consisting of the complete lipoprotein OspA and aluminum hydroxide (adjuvant).The Vaccine
$ 8500 per shot.
Expressed in E. coli strain AR58.
Transformed with plasmid pOA15.
With OspA (a plasmid gene) as its insert.
The lipid moiety was added post-translationalyThe Vaccine cont...
These antibodies possess bactericidal activity.
Antibodies taken in along with tickís bloodmeal.
B. burgdorferi destruction ensues.Mechanism of Action
Here is the key !
10,000 person study. antibodies.
49% effective after two doses.
After three doses 100% effective in preventing asymptomatic infection.Vaccine Efficacy
Lack of long term testing. antibodies.
Is a booster dose needed?
OspA contains a sequence that is similar to the human protein LFA-1.
This could lead to an autoimmune disease.Reservations
Biddle, W. Afield Guide to Germs. New Jeresy: Doubleday Publishing Groupe,1995.
Ginsberg, H.S. Ecology and Environmental Management of Lyme Disease. New Jersey: Rutgers University Press, 1993.
Lang, D. Coping with Lyme Disease. New York: Henery Holt and Company, 1993.
Silverstein, A. Lyme Disease the Great Imitator. New Jersey: Avstar Publishing Corp., 1990.
ìImmunization Against Lyme Disease - An Important First Step.î The New England Journal of Medicine July 23,1998: 263-264.
Marwick, C. ìGuarded Endorsement for Lyme Disease Vaccine.î JAMA June 24, 1998: 1937-1938.
Sigal, L.H. ìA vaccine consisting of Recombinant Bb OspA to Prevent Lyme disease.î The New England Journal of Medicine July 23,1998: 216-221.References
Steere, A.C. ìVaccination Against LD with Recombinant Bb OspA with Adjuvant.î The New England Journal of Medicine July 23, 1998: 209-214.
Telford S.R. ìEfficancy of LD Vaccine Formulations in a Mouse Model.î The Journal of Infectious Diseases May, 1995: 1368-1370.
Sanz C. ìSummer of Danger.î Discover May, 1999: 64-71.
http://www.lymerix.com SmithKline Beecham Bio.
http://www.aldf.com American Lyme Disease Foundation, Inc.
http://www.uri.edu/ticklab The Tick Research Lab.
hppt://www.ent.iastate.edu/imagega Iowa State Entomolgy Image Gallery.
http:www.acponline.org/lyme American Academy of Physicians
http://www.cdc.gov/ncidod/dvbid/lymeinfo.htm Centers for Disease Control and Prevention.
http://thetick.powertie.org Brandons Tribute to the Tick.
Any questions ?