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Sensory, Motor, and Integrative Systems

Sensory, Motor, and Integrative Systems. Dr. Michael P. Gillespie. Sensation. Sensation is the conscious or subconscious awareness of changes in the internal or external environment. Destination of sensory nerve impulses- Spinal cord – reflexes.

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Sensory, Motor, and Integrative Systems

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  1. Sensory, Motor, and Integrative Systems Dr. Michael P. Gillespie

  2. Sensation • Sensation is the conscious or subconscious awareness of changes in the internal or external environment. • Destination of sensory nerve impulses- • Spinal cord – reflexes. • Lower brain stem – heart rate, breathing rate. • Cerebral cortex – we become aware of sensory stimuli. • Perception is the conscious awareness and interpretation of sensations (primarily occurs in the cerebral cortex).

  3. Sensory Modalities • Each unique type of sensation is called a sensory modality. • Touch, pain, vision, hearing, etc. • A given sensory neuron carries information for only one sensory modality. • Two classes of sensory modalities: • General senses. • Special senses.

  4. General Senses • General senses refer to both somatic and visceral senses. • Somatic senses include tactile sensations (i.e. touch, pressure, vibration, itch, tickle), thermal sensations (warm and cold), pain sensations, and proprioceptive sensations. Proprioceptive sensations monitor static positions and movements. • Visceral senses provide information about the organs. • Special senses include the sensory modalities of smell, taste, vision, hearing, and equilibrium or balance.

  5. Process of Sensation • The process of sensation begins in a sensory receptor, which can be either a specialized cell or the dendrites of a sensory neuron. • Each sensory receptor responds to a different stimulus. • The receptor exhibits selectivity.

  6. Sensory Receptor Types

  7. Four Events in Sensation • 1. Stimulation of the sensory receptor. • Stimulation must occur within the receptive field. • 2. Transduction of the stimulus. • The receptor transduces (converts) energy in a stimulus into a graded potential.

  8. Four Events in Sensation • 3. Generation of nerve impulses. • When a graded potential reaches threshold, it triggers one or more impulses. • Sensory neurons that conduct from PNS to CNS are referred to as first order neurons. • 4. Integration of sensory input. • Part of the CNS receives and integrates the sensory nerve impulses.

  9. Types of Sensory Receptors • Sensory receptors can be classified according to several structural and functional characteristics. • 1. Microscopic appearance. • Type of potential produced • Generator potentials and receptor potentials. • 2. Location of receptors and the origin of the stimuli that activate them. • 3. According to the type of stimulus they detect.

  10. Microscopic Structural Characteristics • Free nerve endings of first-order sensory neurons. • Bare dendrites. • Pain, thermal, tickle, itch, and some touch sensations. • Encapsulated nerve-endings of first-order sensory neurons. • Dendrites are enclosed in a connective tissue capsule. • Somatic and visceral sensations such as pressure, vibrations, and some touch sensations. • i.e. pacinian corpuscles.

  11. Microscopic Structural Characteristics • Separate cells that synapse with first-order sensory neurons. • i.e. hair cells for hearing and equilibrium, gustatory receptor cells in taste buds, photoreceptors in the retina of the eye, etc.

  12. Types of Graded Potentials • Sensory receptors produce two kinds of graded potentials in response to a stimulus. • Generator potentials • Occur in dendrites of free nerve endings, encapsulated nerve endings, and the receptive part of olfactory receptors. • When a generator potential is large enough to reach threshold, it generates an action potential in a first-order neuron. • Receptor potentials • Occur in sensory receptors that are separate cells. • Receptor potentials trigger release of a neurotransmitter through exocytosis of synaptic vesicles.

  13. Location of Receptors / Origin of Stimuli • Exteroreceptors • Located at or near the external surface of the body. • Sensitive to stimuli outside the body. • Monitor the external environment. • Hearing, vision, smell, taste, touch, pressure, vibration, temperature, and pain. • Interoreceptors • Located in blood vessels, visceral organs, muscles, and the nervous system. • Monitor the internal environment. • Usually not consciously perceived; however, strong stimuli may be felt as pain and pressure.

  14. Location of Receptors / Origin of Stimuli • Mechanoreceptors • Located in muscles, tendons, joints, and the inner ear. • Provide information about body position, muscle length and tension, and the position and movement of your joints. • There really is no such thing as a proprioceptor. Receptors such as mechanoreceptors participate in proprioceptive pathways. The term proprioceptor is vague and not appropriate; however, its use is ubiquitous in the literature.

  15. Type of Stimulus Detected • Most stimuli are in the following forms: • Mechanical energy – i.e. sound waves or pressure changes. • Electromagnetic energy – i.e. light or heat. • Chemical energy – i.e. a molecule of glucose.

  16. Type of Stimulus Detected • Mechanoreceptors • Sensitive to mechanical stimuli such as the deformation, stretching, or bending of cells. • Provide sensations of touch, pressure, vibration, proprioception, hearing, and equilibrium. • Thermoreceptors • Respond to changes in temperature. • Nociceptors • Respond to painful stimuli from physical or chemical tissue damage.

  17. Type of Stimulus Detected • Photoreceptors • Detect light that strikes the retina of the eye. • Chemoreceptors • Detect chemicals in the mouth (taste), nose (smell), and body fluids. • Osmoreceptors • Detect the osmotic pressure of body fluids. • Baroreceptors

  18. Somatic Sensations • Somatic sensations arise from stimuli of sensory receptors in the skin or subcutaneous layer; in mucous membranes of the mouth, vagina, and anus; in muscles, tendons, and joints; and in the inner ear. • Somatic sensory receptors are distributed unevenly. • Highest density – tip of the tongue, lips, fingertips. • Cutaneous sensations are those arising from stimulating the surface of the skin.

  19. Four Modalities of Somatic Sensation • Tactile • Thermal • Pain • Proprioceptive

  20. Tactile Sensations • The tactile sensations include touch, pressure, vibration, itch, and tickle. • Tactile receptors in the skin or subcutaneous layer include Meissner corpuscles, hair root plexuses, Merkel discs, Ruffini corpuscles, pacinian corpuscles, and free nerve endings.

  21. Structure and Location of Sensory Receptors

  22. Touch • Sensations of touch arise from stimulation of receptors in the skin and subcutaneous layer. • Rapidly adapting touch receptors: • Meissner corpuscles • Corpuscles of touch. • Located in the dermal papillae of hairless skin. • Egg shaped mass of dendrites enclosed by a capsule. • Hair root plexuses • Free nerve endings wrapped around hair follicles.

  23. Touch • Slowly adapting touch receptors: • Merkel discs (tactile discs or type I cutaneous mechanoreceptors. • Saucer shaped, flattened free nerve endings that make contact with Merkel cells. • Plentiful in the fingertips, hands, lips, and external genitalia • Ruffini corpuscles (type II cutaneous mechanoreceptors). • Elongated, encapsulated receptors located deep in the dermis, and in ligaments and tendons. • Present in the hands and soles. • Sensitive to stretching of digits and limbs.

  24. Pressure • Pressure is a sustained sensation that is felt over a larger area than touch. • It occurs with deformation of deeper tissues. • Meissner corpuscles, Merkel discs, and pacinian corpuscles contribute to pressure sensation. • Pacinian corpuscles (lamellated corpuscles) are large oval structures composed of a multi-layered connective tissue capsule enclosing a dendrite. • Located in the dermis and subcutaneous layer; in submucosal tissues; around joints, tendons, and muscles; in the periosteum; and in the mammary glands, external genitalia, and certain viscera, such as the pancreas and urinary bladder.

  25. Vibration • Vibration sensation results from rapidly repetitive sensory signals from tactile receptors. • Meissner corpuscles and pacinian corpuscles detect vibration. • Meissner – lower-frequency vibrations. • Pacinian – higher-frequency vibrations.

  26. Itch • Itch results from stimulation of free nerve endings by certain chemicals, such as bradykinin, often due to a local inflammatory response.

  27. Tickle • Free nerve endings are thought to mediate the tickle sensation.

  28. Thermal Sensations • Thermoreceptors are free nerve endings. • The thermal sensations of coldness and warmth are detected by different receptors. • Temperatures below 10⁰ and above 48⁰C primary stimulate pain receptors.

  29. Thermal Sensations • Cold receptors: • Located in the stratum basale of the dermis. • Attached to medium-diameter type A myelinated fibers. • Temperatures between 10⁰ and 40⁰C activate them. • Warm receptors: • Located in the dermis. • Not as abundant as cold receptors. • Attached to small-diameter unmyelinated C fibers. • Temperatures between 32⁰ and 48⁰C activate them.

  30. Phantom Limb Sensation • Patients who have had a limb amputated may still experience sensations such as itching, tingling, or pain as if the limb were still there. • This is called phantom limb sensation. • Possible causes: • Impulses from the proximal portions of sensory neurons that previously carried impulses from the limb. • Neurons in the brain that previously received input from the missing limb are still active, giving false sensory perceptions.

  31. Phantom Limb Sensation • Treatments such as acupuncture, electrical nerve stimulation, and biofeedback can be helpful in treating phantom limb pain.

  32. Pain Sensations • Pain serves a protective function by signaling the presence of noxious, tissue-damaging conditions. • The subjective description and indication of the location of pain may help identify the underlying disease. • The receptors for pain are called nociceptors (noci = harmful). • They are free nerve endings found in every tissue of the body except the brain.

  33. Pain Sensations • Intense thermal, mechanical, or chemical stimuli can activate nociceptors. • Tissue irritation or injury releases chemicals such as prostaglandins, kinins, and potassium ions that stimulate nociceptors.

  34. Pain Sensations • Pain can persist long after the pain-producing stimulus is removed because the pain mediating chemicals linger. • Conditions that elicit pain include excessive distention (stretching) of a structure, prolonged muscular contractions, muscle spasms, or ischemia.

  35. Types of Pain • Types of pain based upon speed of impulses: • Fast pain • Medium-diameter, myelinated A fibers. • Occurs within 0.1 seconds after a stimulus is applied. • Referred to as acute, sharp, or pricking pain. • Needle puncture or knife cut to the skin. • Not felt in deeper tissues.

  36. Types of Pain • Slow pain • Small-diameter, unmyelinated C fibers. • Begins a second or more after the stimulus is applied. • Increases in intensity over several seconds or minutes. • Referred to as chronic, burning, or throbbing pain. • Can occur in skin, deeper tissues, or internal organs.

  37. Types of Pain • Types of pain based upon location of pain receptors: • Superficial somatic pain – stimulation of receptors in the skin. • Deep somatic pain - stimulation of receptors in skeletal muscles, joints, tendons, and fascia. • Visceral pain – stimulation of receptors in visceral organs.

  38. Localization of Pain • Fast pain • Very precisely localized to the stimulated area. • i.e. pin prick • Somatic slow pain • Well localized, but more diffuse

  39. Localization of Pain • Visceral slow pain • Some is localized to the area of pain • Much is referred to the skin that overlies the organ or to a surface area far from the stimulated organ. • Know as referred pain. • In general, the visceral organ and the area to which the pain is referred are served by the same segment of the spinal cord.

  40. Distribution of Referred Pain

  41. Analgesia • Analgesia (an = without, algesia = pain) is pain relief. • Types of analgesia: • Analgesic drugs such as aspirin and ibuprofen block the formation of prostaglandins, which stimulate nociceptors. • Local anesthetics such as novacaine block the conduction of nerve impulses along the axons of first-order pain neurons. • Morphine and other opiate drugs alter the quality of pain perception in the brain. • Pain is still sensed, but no longer experienced as so noxious.

  42. Proprioceptive Sensations • Proprioceptive sensations allow us to know where our head and limbs are located and how they are moving even if we are not looking at them. • Kinesthesia (kin = motion, esthesia = perception) is the perception of body movements. • Proprioceptive sensations arise in receptors termed mechanoreceptors.

  43. Proprioceptive Sensations • Mechanoceptors are embedded in muscles and tendons. These tell us the degree to which the muscle is contracted, the amount of tension on tendons, and the position of joints. • Hair receptors in the inner ear monitor the orientation of the head relative to the ground and the head position during movements. • The provide information for maintaining balance and equilibrium. • Mechanoreceptors also allow for weight discrimination.

  44. Mechanoreceptors • Three types: • Muscle spindles • Located within skeletal muscles • Tendon organs • Located within tendons • Joint kinesthetic receptors • Located within synovial joint capsules

  45. Muscle Spindles • Muscle spindles are located in skeletal muscles. • They consist of several slowly adapting sensory nerve endings that wrap around 3-10 specialized muscle fibers, called intrafusal muscle fibers. • Muscle spindles monitor changes in the length of skeletal muscles. • The main function of a muscle spindles is to measure muscle length (how much a muscle is being stretched).

  46. Muscle Spindles • They participate in stretch reflexes. • Activation of the muscle spindle causes contraction of a skeletal muscle, which relieves stretching. • They help maintain the level of muscle tone (the small degree of muscle contraction present while the muscle is at rest).

  47. Tendon Organs • Tendon organs are located at the junction of a tendon and a muscle. • They consist of a thin capsule of connective tissue that encloses a few tendon fascicles. • The participate in tendon reflexes to protect tendons and their associated muscles from damage due to excessive tension. • Tendon reflexes decrease muscle tension by causing muscle relaxation.

  48. Muscle Spindles & Tendon Organs

  49. Joint Kinesthetic Receptors • Several types of joint receptors are present within or around the articular capsule of synovial joints. • Free nerve endings and Ruffini corpuscles respond to pressure. • Pacinian corpuscles respond to acceleration and deceleration of the joint. • Articular ligaments contain receptors similar tendon organs that adjust reflex inhibition of adjacent muscles.

  50. Somatic Sensory Pathways • Somatic sensory pathways relay information from the somatic sensory receptors to the primary somatosensory area in the cerebral cortex and to the cerebellum. • Three sets of neurons • First-order neurons • Second-order neurons • Third-order neurons

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