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Challenges and Solutions in Film Coating Processes for Pharmaceutical Tablets

This document discusses common problems encountered in film coating processes for pharmaceutical tablets, such as issues with bed temperature, spray rates, and pigment ratios. It highlights methods to enhance coating quality, including raising bed temperature, adjusting air volume, and optimizing the use of plasticizers and polymers. Key factors like drying parameters and spray nozzle sizes are examined for their impact on coating effectiveness. Solutions to improve film strength, pigment dispersion, and quality of lake color are also presented for industry professionals.

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Challenges and Solutions in Film Coating Processes for Pharmaceutical Tablets

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  1. Problems observed and Faced in film coating

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  6. Raise Bed Temperature • Raise Process Air Volume • Reduce Spray Rate

  7. Correct Plasticiser • Dye Concentration 1. Lake colour quality

  8. Replace Worn Punches 1. Correct Combination of Polymer strength 2. Reduce Pigment Ratio

  9. 1.Correct Ratio of Plasticiser & Polymers.2. Use Combinationof Different polymers

  10. Control Spray Rate • Control Speed of the Pan • Drying Parameters • Tablets without • Flat surface

  11. Correct Pigment content • Improve Film Strength • Quality of Lake Colour • Quality of Plasticizer

  12. Check Spray nozzle size / Droplet size • Better homogenization of • Polymers / Plasticizers / Pigment

  13. 1. Check Spray nozzle size 1. Better dispersion of pigments

  14. Reduce the spray rate . • Lower the Solid content .

  15. Reduce spray rate • Improve drying condition • Increase pan speed

  16. Check slide bars and baffles • Ensure proper rolling of • tablets to provide uniform coating

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