Sulindac Pharmacokinetics. The Role of Flavin-containing Monooxygenases. Brett Bemer Dr. David Williams Laboratory Dr. Sharon Krueger Dr. Gayle Orner HHMI Summer Research 2008. Sulindac: Background. Nonsteroidal anti-inflammatory drug (NSAID) available as Clinoril
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The Role of Flavin-containing Monooxygenases
Dr. David Williams Laboratory
Dr. Sharon Krueger
Dr. Gayle Orner
HHMI Summer Research 2008
Sachse et. al. Pharmacogenetics and Genomics,1999
Typical chromatogram of FMO3 incubation with SS
A typical Lineweaver-Burk plot
Expected band sizes for polymorphism detection
aPrimer pairs from Dolphin et al., 1997 Nat Genet 17:491-4.
bPrimer pairs from Sachse et al., 1999 Clin Pharmacol Therap 66:431-8.
cPrimer pairs from Dolphin et al., 2000 Pharmacogenetics 10:799-807.