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CPSC485 Computational Bioinformatics

CPSC485 Computational Bioinformatics. Shawn X Wang, Ph.D. What is bioinformatics?. (Wikipedia) Bioinformatics is the application of information technology to the field of molecular biology.

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CPSC485 Computational Bioinformatics

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  1. CPSC485 Computational Bioinformatics Shawn X Wang, Ph.D.

  2. What is bioinformatics? • (Wikipedia) Bioinformatics is the application of information technology to the field of molecular biology. • (NIH) Bioinformatics is the field of science in which biology, computer science, and information technology merge to form a single discipline. • (Simply put) Bioinformatics is the acquisition, organization, analysis, interpretation, visualization, and utilization of biological data that may reveal new insights or principles

  3. DNA • Deoxyribonucleic Acid • Basic building blocks of organisms • Located in nucleus of cells • Composed of 4 nucleotides • Adenine (A) • Cytosine (C) • Guanine (G) • Thymine (T) • Two strands bound together • Contains genetic information of individual

  4. Nucleotide Bases

  5. DNA Replication

  6. Transcription • During transcription, DNA is converted to create mRNA • RNA is processed and non-coding regions removed • Coding regions are converted to form protein • Enzyme (RNA Polymerase) that starts transcription by binding to DNA code .

  7. RNA • Ribonucleic Acid • Contains A,C,G but U (Uracil) instead of T • Single Stranded • May fold back on itself • Needed to create proteins • Move around cells – can act like a messenger • mRNA – moves out of nucleus to other parts of cell

  8. Translation • Synthesis of Proteins from mRNA • Nucleotide sequence of mRNA converted into amino acid sequence of protein • Twenty amino acids • Codon – Group of 3 nucleotides • Amino acids have many codings

  9. Protein • Composed of 20 amino acids

  10. DNA transcription RNA translation Protein

  11. How useful is bioinformatics? • E. Coli O157:H7 or O104:H21 • HIV • Human Genome Project • Evolution study

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