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ONAMI

Issues for Nanotechnology. Growing concerns about ecotoxicity, human ... Nanoscience and Nanotechnology, 2001) Importance of public acceptance. Perceptual risks ...

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ONAMI

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    1. ONAMI’s - Safer Nanomaterials and Nanomanufacturing Initiative Recommendations for the FDA Nanotechnology Task Force Stacey Harper

    2. Issues for Nanotechnology

    3. Safer Nanomaterials and Nanomanufacturing Initiative (SNNI)

    4. Designing safer nanoparticles

    5. Testing the biological impacts of engineered nanoparticles Tier 1: Toxicity Screening Toxicity testing in cells, tissues and whole organisms In vitro (human cells, tissue cultures) In vivo (vertebrate models) Tier 2: Cellular Targets and Distribution Defined in vivo Fluorescent nanomaterials Targeted assays Tier 3: Molecular Expression Molecular (genetic) response Whole animal gene expression profiles Vertebrates

    6. A diverse family of functionalized nanoparticles has been prepared for 1.5-nm and 0.8-nm core sizes

    7. Example: Toxicity affected by size and surface functionalization

    8. Recommendations

    9. Contact Information

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