Dyspnea. a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity
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consequence of interactions between the efferent, or outgoing, motor output from the brain to the ventilatory muscles (feed-forward) and the afferent, or incoming, sensory input from receptors throughout the body (feedback) as well as the integrative processing of this information occurring in the brain
given disease state may lead to dyspnea by one or more mechanisms, some may be operative under some circumstances