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MRC Lifecourse Epidemiology Unit Cyrus Cooper, Director. MRC LEU ; Southampton 2013. MRC Lifecourse Epidemiology Unit 2010-2015. . Fetus & Infant. Child. Aetiology. . Research focus. Research focus. Mechanisms. Intervention. . Adult. Lifecourse epidemiology. Programmes.

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Presentation Transcript
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MRC Lifecourse Epidemiology Unit

Cyrus Cooper, Director

MRC LEU; Southampton 2013

slide2

MRC Lifecourse Epidemiology Unit

2010-2015

Fetus &

Infant

Child

Aetiology

Research focus

Research focus

Mechanisms

Intervention

Adult

Lifecourse epidemiology

Programmes

Programmes

Work and Health

Musculoskeletal ageing

Nutrition, development,

and lifelong health

  • Scientific Mission
  • To delineate:
  • The environmental causes throughout the lifecourse of
  •  chronic musculoskeletal disorders
  •  obesity, type 2 diabetes and cardiovascular disease
  • Population-based and high-risk preventive strategies against these disorders

Mission

Mission

slide3

Young women’s diet, body composition, physical activity, education and lifestyle before and during pregnancy

Developmental plastic responses

Epigenetic processes

Infant body composition & development

Weight gain and catch-up growth

Infant feeding and illnesses

MECHANISMS

BEHAVIOURS

Childhood body composition and development

Childhood diet, physical activity, lifestyle and education

Work, lifestyle and health behaviours in adulthood

Vulnerability to chronic disease in later life

Retirement and ageing

Lifecourse determinants of health and disease

Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Harvey N, Cooper C BMJ 2012; 345: e4695

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Lifecourse strategy for disease prevention

No intervention

Late intervention impactful for

vulnerable groups

Chronic NCD risk

Adulthood

Late intervention

Childhood

Earlier intervention improves functional

capacity & responses

to new challenges

Mother

& infant

Early intervention

Life course

Plasticity

Inadequate response

to new challenges

Gluckman, Hanson, Cooper et al New Engl J Med 2008; 359: 61-73 Hanson M , Godfrey K et al Prog Biophys Molec Biol 2011; 106: 272-280

scientific programmes
Scientific Programmes
  • Lifecourse determinants of bone and joint disease
  • Sarcopenia, physical frailty and clinical care in older people
  • Nutrition, development and lifelong health (Developing/transitioning populations)
  • Nutrition, development and lifelong health (Developed populations)
  • Work and Health
scientific achievements
Scientific achievements

Maternal vitamin D insufficiency and childhood bone mineral accrual

Developmental origins of sarcopenia and cognitive function

Maternal micronutrient status, birthweight and childhood adiposity

Self-efficacy and control as determinants of food choice among young women

Health beliefs, somatising tendency, physical exposures and musculoskeletal disability