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Effect of GTP-γ-S on Calcium Current in Cell Membranes: An Electrophysiological Study

This study examines the impact of GTP-γ-S on calcium current in cell membranes, using electrophysiology techniques. Results show significant alterations in current at various membrane potentials. Findings suggest regulatory roles of GTP-γ-S in cellular signaling pathways.

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Effect of GTP-γ-S on Calcium Current in Cell Membranes: An Electrophysiological Study

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  1. 120 mV A B C 0 mV -90 mV GTP--S 0.5nA GTP--S + PP. 30ms GTP--S Ctrl GTP--S & PGB 0 0mV 0mV 0mV -90 mV -0.2 GTP--S GTP--S +PGB -0.4 Ca2+ Current (nA) -0.6 0.5nA Control 20ms -0.8 -1.0 n=5 P<0.05 P<0.05 PGB & GTP--S Ctrl PGB 0mV 0 -90mV -0.5 PGB & GTP--S Ca2+ Current (nA) PGB -1.0 Control n=4 P<0.05 0.5nA -1.5 20ms P<0.05

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