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Drugs: Magnesium Sulphate; Gentamicin; Amoxicillin & Cefuroxime. - Oriana, Lyndsay & Nicky. GENTAMICIN. Antibiotic – what are antibiotics? Molecules produced naturally by other organisms to combat the threat to themselves.
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- Oriana, Lyndsay & Nicky
Molecules produced naturally by other organisms to combat the threat to themselves.
Mode of action is to inhibit some essential function of bacterial cell’s life cycle
Bactericidal, active against some Gram-positive and many Gram-negative organisms
Mode of action is to prevent part of cell that makes proteins (ribosome) from working
Known as protein synthesis inhibitors
Not absorbed from the gut, therefore given by injection
Excretion mainly from kidneys but filtered unchanged, therefore accumulation occurs in renal impairment
- septicaemia, neonatal sepsis, meningitis,
biliary-tract inefections, endocarditis,
pneumonia in hospital patients
- dose adjusted for weight (3-5mg/kg)
- dose no more frequent than once daily
- peak and trough levels to be measured
Aggravation of myasthenia by blocking neuromuscular transmission
Blood sample should be taken approximately 1 hour after intramuscular or iv administration (peak serum concentration), and just before next dose (trough serum concentration)
Administered for treatment of septic shock
When used for ‘blind’ therapy of undiagnosed serious infections, it is usually given in conjunction with penicillin or metronidazole, or both.
Could this be the reason why Simon was given Amoxycillin?
Amoxicillin, Ampicillin, Benzylpenicillin, Co-amoxiclav, Flucloxacillin, Phenoxymethylpenicillin.
Gould D (2004) Bacterial infections: antibiotics and decontamination. Nursing Standard, 18 (40),p. 38-42.
- rash, wheezing, itching or oral swelling.
- ie: penicillin's.
(Henderson N (1998) Anaphylaxis. Nursing Standard. 12, 47, 49-55)
- ensures safe and consistent practice.
Erythromycin (class: Macrolides):
Community-acquired: Septicaemia: (initial ‘blind’ therapy)
Hospital-acquired: Septicaemia: (initial ‘blind’ therapy)
NOT IN PEN ALLERGY
- Hypomagnesemia – causes contraction
- Hypermagnesemia – causes relaxation