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Medical Terminology. Endocrine System Chapter 14. The functions of the endocrine system cover a broad range of action. Endocrine activity affects the entire body: growth and development, metabolism, sexual activity, and even mental ability and emotions.

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medical terminology

Medical Terminology

Endocrine System

Chapter 14

slide2
The functions of the endocrine system cover a broad range of action. Endocrine activity affects the entire body: growth and development, metabolism, sexual activity, and even mental ability and emotions.

The endocrine system is a means of communication between one body part and another.

anatomy and physiology
Anatomy and Physiology
  • Homeostasis
    • state of equilibrium
  • Hormones (chemical messengers)
  • Target Tissues or Target Organs
  • Hypersecretion
  • Hyposecretion
hormones
Hormones
  • chemical substances produced by specialized cells (glands)
  • released slowly, minute amounts, circulate in blood
  • some hormones effect the entire body, some effect target organs
  • most hormones are inactivated or excreted by the liver and kidneys
pituitary or master gland
Pituitary or Master Gland
  • posterior lobe
    • neurohypophysis
  • anterior lobe
    • adenohypophysis
anterior lobe
Anterior Lobe
  • growth hormoneGH somatotropin
  • thyroid-stimulating hormone TSH
  • lactogenic hormone Prolactin
  • adrenocorticotropic hormone ACTH
  • follicle-stimulating hormone FSH
  • luteinizing hormone LH
posterior lobe
Posterior Lobe
  • antidiuretic hormone ADH
    • decrease ADH causes increase urine output
    • increase ADH causes decrease urine output
  • oxytocin
    • stimulates contraction of pregnant uterus, labor, and childbirth
    • stimulates milk secretion
thyroid secretions
Thyroid Secretions
  • thyroxine, T4
  • triiodothytonine, T3
  • regulates rate of cellular metabolism
  • influences physical and mental development
  • euthyroidism
slide10
stimulates cellular metabolism by increasing the rate of oxygen use with subsequent energy and heat production
  • Faster cellular metabolism increases the cell’s demand for oxygen, so more O2 must be circulated.
  • Increase O2 demand leads to increase CO2
  • Increase demand on circulatory system leads to increase pulse rate and heart activity.
parathyroid glands
Parathyroid Glands
  • four glands
  • parathyroid hormone PTH
  • regulates the level of circulating calcium and phosphate
  • target organs: bones, intestines, kidneys
slide12
Calcium is essential to blood-clotting mechanism
  • Calcium increases the tone of heart muscle
  • Calcium plays a significant role in muscle contraction
  • When blood calcium levels drop, PTH is secreted to increase calcium levels
adrenal glands
Adrenal Glands
  • suprarenal glands
  • adren/o or adrenal/o
  • adrenal cortex
  • adrenal medulla
adrenal cortex
Adrenal Cortex
  • stimulated by ACTH from anterior pituitary
  • mineralocorticoids - regulates water & salts
    • aldosterone
  • glucocorticoids - regulates carbohydrate, lipid, and protein metabolism
    • cortisol
  • sex hormones
    • androgens - male
    • estrogen - female
adrenal medulla
Adrenal Medulla
  • epinephrine or adrenaline
    • secreted in stress situations
    • stimulates sympathetic nervous system
    • increases HR, blood glucose, stimulates BP
    • vasoconstriction to shunt blood
  • norepinephrine or noradrenaline
    • powerful vasopressor to increase BP
pancreas
Pancreas
  • Endocrine and exocrine functions
  • islets of Langerhans
  • glucagon (Alpha cells)
    • stimulates liver to convert glycogen to glucose
  • insulin (Beta cells)
    • transports glucose into cells for metabolism and energy source
pineal gland
Pineal Gland
  • melatonin-may control biological cycles
    • inhibit ovarian activity
  • serotonin-neurotransmitter, vasoconstrictor
    • stimulates smooth muscles and inhibits gastric secretion
pituitary pathology
Pituitary Pathology
  • Growth Hormone GH
    • dwarfism - hyposecretion
    • giantism, acromegaly - hypersecretion
  • Thyroid Stimulating Hormone TSH
    • cretinism (infants) - hyposecretion
    • myxedema (adults) - hyposecretion
    • Toxic goiter (adults - hypersecretion
      • exophthalmos
pathology of thyroid gland
Pathology of Thyroid Gland
  • anterior pituitary (TSH) controls circulating thyroxine level
  • thyroiditis
  • hypothroidism
  • Myxedema
  • cretinism
slide20
thyrotoxicosis, thyroid storm
  • hyperthyroidism
  • goiter or thyromegaly
  • exophthalmos
procedures of thyroid gland
Procedures of thyroid gland
  • thyroidectomy
  • lobectomy
pathology of parathyroid
Pathology of Parathyroid
  • hypoparathyroidism
  • hypocalcemia
    • lowers electrical threshold
    • causes neurons to depolarize easier
  • tetany
    • sustained muscular contraction
    • laryngeal muscle spasms leading to respiratory tract obstruction and death
    • sharp flexion of some skeletal muscles
parathyroid disorders hyperparathyroidism
Parathyroid DisordersHyperparathyroidism
  • hyperparathyroidism
    • often due to benign tumor
    • demineralization of bones (osteitis fibrosa cystica)
    • osteoporosis
pathology
Pathology
  • pheochromocytoma
    • adrenal medulla tumor
    • increase BP due to release of catacholamines
  • Addison’s disease - decrease cortisol
    • hyponatremia, dehydration
    • hyperkalemia
  • Cushing’s disease - increase cortisol
    • moon face, hirsutism
diabetes mellitus
Diabetes Mellitus
  • inadequate amount of insulin secreted
  • in absence of insulin; glucose cannot enter the cells for normal metabolism
  • results in hyperglycemia
  • blood sugar may increase from 300 to 1200 mg/dl of blood and even higher
  • cells deprived of principal nutrient, glucose
  • glycosuria, diuresis, polydipsia, polyphagia
slide26
Insulin-dependent diabetes mellitus IDDM
    • Type I
    • Juvenile diabetes
    • destruction of Beta cells
    • more serious form
    • requires daily insulin injections
slide27
Non-insulin-dependent diabetes mellitus
    • NIDDM
    • type II
    • maturity onset diabetes
    • less severe, often diet controlled
    • oral hypoglycemic agents
  • A prolonged, excessively high carbohydrate diet over time stimulates the beta cells to secrete insulin. Result: beta cells “burn out”.
slide28
diabetic ketoacidosis (acidosis)
    • due to insulin deficiency, stress
    • metabolic shift results in excessive accumulation of ketones
  • gestational diabetes mellitus
    • deficiency of insulin during pregnancy
slide29
Diabetes Insipidus
    • Insufficient ADH
    • Inability of kidneys to respond to ADH
  • extreme polydipsia and polyuria
oncology
Oncology
  • Pancreatic Cancer
  • Pituitary Tumors
  • Thyroid Cancer
end chapter 14

End Chapter 14

Endocrine System