1 / 12

Exploring Hematopoietic Elements in Histology for Pathology

Learn to identify and understand erythrocytes, platelets, neutrophils, and more in blood smears and tissues. Discover cell development sequences and components of bone marrow. Define key terms and interpret various cell types.

annlewis
Download Presentation

Exploring Hematopoietic Elements in Histology for Pathology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Histology for PathologyHematopoietic Elements Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP Assistant Professor Assistant Director of Mechanisms of Human Disease Loyola Stritch School of Medicine

  2. Objectives • On a peripheral blood smear identify the following cells: erythrocytes, platelets, neutrophils, eosinophils, basophils, lymphocytes and monocytes. • On a peripheral blood smear identify neutrophil band cells (also known as stab cells) and state the clinical significance of their presence. • On H&E stained sections, identify neutrophils, eosinophils, lymphocytes. • On H&E sections identify plasma cells. • On a stained section identify the 3 major components of bone marrow (bone trabeculae, hematopoietic cells, adipose tissue). • List the sequence of development of a granulocytes – focusing on the neutrophil. • On a section of bone marrow, identify a megakaryocyte. • Define “blast cell”.

  3. Granulocytes – Peripheral Blood Smear Neutrophil Eosinophil Basophil

  4. Agranulocytes – Peripheral Blood Smear Lymphocyte Monocyte

  5. Peripheral Blood Smear Red blood cells Platelets

  6. H&E Stained Sections Eosinophils Neutrophils

  7. H&E Stained Section

  8. H&E Section – Plasma Cells

  9. Bone Marrow Bone Hematopoietic cells Adipose (fat) cells

  10. Based on this representative section of normal bone marrow, what is the age the patient?

  11. Granulocytopoiesis B C E F A G Neutrophilic series A = Myeloblast B = Myelocyte (large cell, rounded nucleus) C = Late myelocyte or early metamyelocyte (nucleus beginning to indent) E = Metamyelocyte (indented nucleus) G = Band cell (much thinner nucleus) F = Segmented (mature) neutrophil

  12. Megakaryocyte(Mega = Giant)Fragments of cytoplasm break off to become platelets

More Related