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Human Papillomavirus

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Human Papillomavirus

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    1. Human Papillomavirus By Erin Collins

    2. What is HPV Papillomaviruses are classified in the family papoviviridae. Group 1 virus which are dsDNA viruses. There are over 100 different HPVs that have been identified today.

    3. EM of papillomavirus

    4. Types of HPV

    5. Supergroup A Genitally transmitted viruses. May cause warts, lesions, or pre-malignant cell abnormalities.

    6. Supergroup B Transmitted by means other than genital. Passed though skin to skin contact most frequently. Causes warts or lesions in places other then genital.

    7. Types of HPV

    8. Life cycle Nonenveloped virus enters cells through lesions or abrasions in epithelial cells. Initial infection occurs in the basal layer After infection and uncoating occurs HPV enters latency phase for months to years. HPV keeps low levels of viral episome in basal cells of epithelium Virus expresses oncogenes that interfere with host cell cycle and normal termination of cells.

    9. Who is at risk? Everyone is at risk. Immuno-compromised individuals are more likely to experience diseases associated with HPV. 440 million are infected around the world(WHO) 250,000 women die from cervical cancer caused by HPV yearly.(WHO) 74% of new cases are in people 15-24 years old.(CDC)

    10. Disease HPVs are characterized by the type of disease they cause. Low-risk HPVs cause warts High-risk HPVs cause cancer Warts, skin lesions, pre-malignant, and cancerous tumors can all be diseases associated with HPV

    11. Examples of HPV

    12. Cancer Worldwide

    14. Diagnosis HPV goes undetected in most cases. Warts are visually identified. Lesions are visually identified. Cellular abnormalities are identified by pap tests. No point to diagnose virus infection because they usually clear in months to year.

    15. Pap Test

    16. Prevention Abstinance is the only 100% way to prevent HPV. Condoms prevent some types. Monogamous relationships, however even this doesnt work if your partner has been infected. 50% of sexually active people acquire HPV.

    17. Treatment NO CURE FOR HPV. Treatments only treat effects of HPV. Warts can be removed by freezing, burning, or surgically removing the wart.

    18. Vaccine Gardasil is the vaccine currently out for HPV. It protects against HPV types 6, 11, 16, and 18. HPV 16 and 18 cause 70% of cervical cancer cases HPV 6 and 11 cause 90% of genital warts cases.

    19. Problems with Vaccine Only for women (mostly 9-26) Doesnt cure Only prevents HPV if you havent already gotten it. Must be kept cold in storage so it is hard to take to different countries.

    21. Recent Studies Create vaccine that can be stored at room temperature in order to reach countries that cant obtain the current vaccine. Develop treatment that will inhibit E5,6 and 7 proteins that interfer with host cell cycle functions.

    22. One Less http://youtube.com/watch?v=hJ8x3KR75fA

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