Hutchinson-Gilford progeria syndrome (HGPS). PRESENTATION BY DELTA CELL. OUTLINE. BACKGROUND: Etymology and History EPIDEMIOLOGY AETIOPATHOGENESIS CLINICAL FEATURES DIFFERENTIAL DIAGNOSES
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Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare hereditary disease that affects the skin, musculoskeletal system, and vasculature. HGPS is characterized by signs of premature aging.
Progeria is a rare genetic condition that produces rapid aging in children.
Evidence of Hutchinson-Gilford progeria syndrome (HGPS) begins within the first 2 years of life. At birth, infants usually appear healthy, although sclerodermatous skin changes have been noted in some patients. Typically, the onset of the disease occurs at age 6-12 months, when skin changes and alopecia are first noted and when the infant fails to gain weight.