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P026

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AD Biomarkers

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P026

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  1. ALZHEIMER'S DISEASE INTEGRATIVE NEUROIMAGING ASSOCIATED WITH BIOMARKERS IN CEREBROSPINAL FLUID AND COGNITIVE PERFORMANCE Μπουγέα Α.1, DegirmenciY.2 NKUA Department of Neurology, School of Medicine, Istanbul Health and Technology University, 34093 Istanbul, Turkey.

  2. Αim • Amyloidβ  (Aβ)  and  tau  protein  buildup  in  the  brain,  as seen by cerebrospinal fluid (CSF) research, are hallmarks of Alzheimer's disease (AD). • The relationship  between  CSF biomarkers, neuroimaging, and cognition is still unclear. • Our aim was to investigate the  relationships  between  AD  patients'  cognitive   function,   CSF  biomarkers,  and neuroimaging  characteristics.

  3. Methods •  40 individuals with a clinical diagnosis of AD who had Aβ42 pathology based on CSF analysis were included in this research. • They received neuroimaging evaluations of white matter hyperintensities (WMHs) using T2weighted or fluidattenuated inversion recovery images, cerebral blood flow (CBF) using single photon  emission computed tomography, and gray matter volume  using T1-weighted MRI. • Significantimaging findings  pertaining  to CSF biomarkers and MiniMental  State  Examination  (MMSE)  scores  were  found  using  partial  least square (PLS) regression.

  4. Results • While WMHs in the parietal and frontal periventricular areas were negatively connected with CSF Aβ42 levels, lateral temporal and occipital gray matter volumes were positively connected with MMSE scores. • The association between cognition and the gray matter volume of temporo-occipital regions was mediated by CBF in the lateral temporal lobe. • SEM analysis revealed that a lower MMSE score was explained by a correlation between higher WMHs and a lower CSF Aβ42. • The MMSE score was similarly impacted by lateral temporal CBF.

  5. Conclusions • This combined neuroimaging and biomarker investigation demonstrates that lateral temporal lobe neurodegeneration and amyloid pathology via WMHs both independently contribute to cognitive impairment in AD patients.

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