Variety of mating systems. Panmixia Assortative mating Disassortative mating Outcrossing Inbreeding Mixed mating. Disassortative mating. What is the equilibrium frequency of alleles S1, S2, S3, and S4? What is the fate of a new mutation that produces allele S5?. Inbreeding.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
What is the equilibrium frequency of alleles S1, S2, S3, and S4?
What is the fate of a new mutation that produces allele S5?
What is inbreeding?
Forms of inbreeding
Loss of heterozygosity
Do allele frequencies change (i.e., does inbreeding result in evolution)?
Genetic variance within lines:
Genetic variance among lines:
Response to selection among lines:
Fitness of inbred lines:
F ranges from 0-1
F can be thought of as:
F is measured relative to some starting population, which is usually assumed to have F = 0
From Hartl and Clark Fig. 4.15
AA: p2 + pqF
Aa: 2pq - 2pqF
aa: q2 + pqF
HI = observed heterozygosity at neutral loci (usually with molecular markers)
HT = heterozygosity expected under H-W (2pq)
Aa: 2pq - 2pqF = HI
2pq(1-F) = HI
HT(1-F) = HI
F = 1-(HI/HT)
F = (HT-HI)/HT
What is inbreeding depression?
What causes inbreeding depression?
How do organisms avoid inbreeding depression?
Scientists find no biological reason to stop first cousins from marrying
By Denise Grady
The New York Times
Thursday, April 4, 2002
By exposing recessive alleles to selection in homozygotes: