University of Tabuk Faculty of Applied Medical Science Department of Medical Laboratory Technology. Basic Immunology. Mr.AYMAN.S.YOUSIF MSc.Medical Microbiology & Immunology. Academic Year: 1433-1434 (2012-2013). Arms of Immune System. Innate Immunity.
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At the end of this lecture, you should be able to:
1. Factors that LimitEntryof Microorganisms Into The Body.
A. Anatomical Barriers To Infections.
2. Factors that Limitgrowth of Microorganisms Into The Body.
B. Humoral Barriers To Infection. (Humoral components)
C. Cellular Barriers To Infection (cellular components )
Innate immunitylargely involves granulocytes and macrophages (although macrophages can influence adaptive immunity)
Adaptive immunity is mediated primarily by B and T lymphocytes
other cells are regulatory or involved with both adaptive and innate immunity and/or are precursors of another cell type
Polymorphonuclear Neutrophilic Leukocytes, a.k.a., PMNs. They are shorter lived than macrophages but have greater killing power.
Eosinophils are involved in allergic responses, inflammation, and release of Histamine; Histamine is released by Basophils.
e.g. Neutrophil only kill microbe .
Macrophage (MQ) & Dendritic cell(DC)
Kill microbe and present Ag to Components of Acquired immunity specially Helper T cells (CD4) Which activate Acquired immunity