Drug Delivery with liposome. Pei Hsuan Wu Yi Chieh Chung. What is a liposome?. Spherical vesicles with a phospholipid bilayer. 50-100 nm. Hydrophilic. Figure 1. liposome. Figure 2. Phospholipid bilayer. Hydrophobic.
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Pei Hsuan WuYi Chieh Chung
Liposomes were first observed by British haematologist Alec D Banghamin 1961 (published 1964), at the Babraham Institute, in Cambridge
Because the phospholipid bilayer is thin and fragile, it need good nano-technology to control and Manufacture.
Figure 3. TEM images of liposome 
Due to the hydrophilic
and hydrophobic of the phospholipid layer.
Unmodified liposomes gather in specific tissue.
alter liposome surface with ligand
temperature or pH sensitive liposomes
Examples:leishmaniasis, amphotericin B……
Figure 4. Cancer cell
Pretend to be Erythrocyte
PEG Liposome Coating
Sialic acid Coating
Figure 5. Erythrocyte
Affect the time in which the drug is released.
Prolong time -increase duration of action anddecrease administration.
Figure 6. Macrophage
system – “Stealth”Effect
Drug stays in liposome until
it reaches “permeable” tissue
Passive Tumor Targeting
Skin = 0.5 µg/g
Analysis of Drug Levels
.1Plasma Levels: prolonged half-lifePLD vs. doxorubicin (Single Dose, 50 mg/m2)
PLD (T½=50-80 hours)
Hours After Infusion
Gabizon et al., Cancer Res. 1994
Harrington et al.,
Clin. Cancer Res. 2001