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KHYG1

Supplemental figure S1. IP: JAK3 IB: STAT3. IP: JAK3 IB: JAK3. Ig. NKL. SNK6. MEC04. KHYG1. Normal NK. MEC04+IL-2. Supplemental figure S2. SNK6 cell line. 10. 8. 0. 6. 5. Proliferation (x10 5 /mL). WHI-P154 (µM). 10. 20. 4. 50. 2. 0. Day 1. Day 2. Day 0.

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KHYG1

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  1. Supplemental figure S1 IP: JAK3 IB: STAT3 IP: JAK3 IB: JAK3 Ig NKL SNK6 MEC04 KHYG1 Normal NK MEC04+IL-2

  2. Supplemental figure S2 SNK6 cell line 10 8 0 6 5 Proliferation (x105/mL) WHI-P154(µM) 10 20 4 50 2 0 Day 1 Day 2 Day 0

  3. Supplemental figure S3 A. Vehicle Galardin 10 µM MEC04

  4. Supplemental figure S3 B. Vehicle Galardin 10 µM MDA-MB231 16 P < .0001 14 12 10 Number of invasive cells/microscopic field 8 6 4 2 0 Vehicle Galardin

  5. Supplemental figure S3 C. MDA-MB231 Vehicle 20 * ** *** 18 16 14 12 Number of invasive MDA-MB231 cells per microscopic field 10 8 6 4 2 CP-690550 50 nM 0 Vehicle CP-690550 50 nM CP-690550 500 nM M475 500 nM CP-690550 500 nM

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