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Grupo de Genómica Evolutiva

La Arqueología del Genoma. Grupo de Genómica Evolutiva. Dr. Luis José Delaye Arredondo ldelaye@ira.cinvestav.mx. Departamento de Ingeniería Genética. Parte 1: las moléculas como documentos históricos. N. N. La secuencia completa de la insulina (1955). Frederick Sanger.

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Grupo de Genómica Evolutiva

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  1. La Arqueología del Genoma • Grupo de GenómicaEvolutiva Dr. Luis José DelayeArredondo ldelaye@ira.cinvestav.mx Departamento de IngenieríaGenética

  2. Parte 1: lasmoléculascomodocumentoshistóricos N N

  3. La secuenciacompleta de la insulina (1955) Frederick Sanger 1958 Nobel Prize in Chemistry

  4. .. Since all insulins show the same activity it could be concluded that differences would be found only in parts of the molecule that were not important for activity. Frederick Sanger Sanger, F., 1952 Adv. Protein Chem. 7:1-67

  5. Genome map of the circular genome of the single-stranded DNA bacteriophage phi-X174

  6. Frederick Sanger (1918)

  7. Molecules as Documents of Evolutionary History By Emile Zuckerkandl and Linus Pauling (1965) 1. The chemical basis for a molecular phylogeny. Of al1 natural systems, living matter is the one which, in the face of great transformations, preserves inscribed in its organization the largest amount of its own past history. Using Hegel's expression, we may say that there is no other system that is better “aufgehoben” (constantly abolished and simultaneously preserved). We may ask the questions where in the now living systems the greatest amount of their past history has survived and how it can be extracted.

  8. EmileZuckerkandl Linus Pauling

  9. ~

  10. Parte 2: la teoría neutral de evolución molecular N N

  11. EscuelaClásica EscuelaBalanceadora ++++++++++m+++++ AbcDeFGHijKlmnOp ++++++++++++++++ abcdEfGhiJkLmnOP HJ Muller T Dobzhansky Variacióngenéticabaja Variacióngenéticaalta Selección natural comofuerzapurificadora Selección natural mantiene la variacióngenética

  12. Richard C. Lewontin and J. L. Hubby (1966)

  13. After Page and Holmes (1998)

  14. Costo de la selección natural Cargasegregacional Cargasustitucional

  15. Distintas tasas para distintas proteínas fibrinopéptidos hemoglobina número de aa distintos histonas tiempo de divergencia

  16. After Page and Holmes (1998)

  17. Kimura

  18. After Page and Holmes (1998)

  19. After Page and Holmes (1998)

  20. After Page and Holmes (1998)

  21. After Page and Holmes (1998)

  22. Evidence for Rate Constancyin Hemoglobin After Page and Holmes (1998)

  23. Delaye et al 2010

  24. Comparison of individual codon usage in the mt genome of Priapuluscaudatus against average codon usage from a diversity of completed metazoan mt genomes Webster et al 2007

  25. Rate of gene evolution Fast Slow

  26. Parte 3: Brevisimahistoria de los métodos de reconstrucciónfilogenética N N

  27. TaxonomíaNumérica Michener and Sokal (1957)

  28. WilliHennig (1913 - 1976) GrundzügeeinerTheoriederPhylogenetischenSystematik (Hennig, 1950) PhylogeneticSystematics (Hennig, 1966)

  29. Tipo de dato Sitios (nucleótidos o aminoácidos) Matríz de distancia UPGMA Clustering Neighbor joining Métodoparaconstruir la filogenia Máximaparsimonia Criterio de optimización MétodosBayesiandos Evolución mínima Máximaverosimilitud After Page and Holmes (1998)

  30. ¡Gracias! N N

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