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The Problem is Large. 16,000 CR-BSI in U.S. ICUs annuallyMortality: 18% (0-35%)Annual deaths: 500 - 4,000Cost per episode: $28,690-$56,000 Annual cost: $60 - $460 millionCDC. MMWR 2002; Heiselman JAMA 1994; Dimick Arch Surg 2001 . What is the Evidence?. . Guidelines for the Prevention of

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