Plasma proteins. Lecture 3. Functions. Transport Storage Defense Blood clotting Maintenance of oncotic pressure. Transport proteins. Measurment of proteins. Total protein along with relative distribution of major proteins. Measurment of specific proteins. Total protein.
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A substance produced by tumour or by the host in response to tumour from normal tissues.
May be present in blood, urine or tissues.
Mostly they are antigens
May be cytoplasmic proteins, enzymes and hormones.
Be specific to the tumor
Level should change in response to tumor size
An abnormal level should be obtained in the presence of micrometastases
The level should not have large fluctuations that are independent of changes in tumor size
Levels in healthy individuals are at much lower concentrations than those found in cancer patients
Predict recurrences before they are clinically detectable
Test should be cost effective