MLH1 and Hereditary Non-Polyposis Colorectal Cancer. An investigation of DNA mismatch repair By: Daniel Driskill March 22, 2007. HNPCC. Aka: Lynch Syndrome Susceptibility to: Endometrial, stomach, ovarian, and urinary tract, and colon carcinomas Very specific criteria for diagnosis
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An investigation of DNA mismatch repair
By: Daniel Driskill
March 22, 2007
MLH1 + PMS2
Chen et. al. (2005) Cancer Res. 65, 8662-8670
Robertson, et. al. (2006) J. Biol. Chem. 281, 19949–19959.
Inability to properly detect and repair sequence mismatches leads to
high rates of mutations
in microsatellite repeat regions.