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Introduction to the Institute of Translational Health Sciences. Kim Folger Bruce, PhD Director of Research Partnerships. July 17, 2009. Learning Objectives. Learn about the ITHS cores and available services that support clinical and translational research teams

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introduction to the institute of translational health sciences

Introduction to the Institute of Translational Health Sciences

Kim Folger Bruce, PhD

Director of Research Partnerships

July 17, 2009

learning objectives
Learning Objectives
  • Learn about the ITHS cores and available services that support clinical and translational research teams
  • Learn how to navigate the new ITHS website
  • Learn how to become a member
iths overview
The ITHS is part of a national consortium, the Clinical and Translational Science Awards (CTSA), and is funded from the National Center for Research Resources, part of the National Institutes of Health. www.ctsaweb.org

The Institute is a partnership between the University of Washington, Seattle Children’s, the Fred Hutchinson Cancer Research Center and other local/regional institutions dedicated to improving human health.

Helps researchers obtain the education, resources and collaborations necessary to translate discoveries into practice.

ITHS Overview
iths mission
ITHS Mission

The ITHS mission is to create, enable, and sustain innovative translational research and collaborations across disciplines and professions which will accelerate the development of concepts and tangible products that will improve human health.

Our common purpose is to:

  • Foster innovative research and research partnerships
  • Create and sustain research resources
  • Ensure a translational research pipeline through robust education and career development programs
definition of translational research
Definition of Translational Research

Translational research involves moving knowledge and discovery gained from the basic sciences to its application in clinical and community settings. This concept is often summarized by the phrases "bench-to-bedside" and "bedside-to-community" research.

phases of translation
Phases of Translation

Translational research has been described in phases of translation, or "T-phases."

The ITHS has adopted a model of 5 phases (T0-T4).

  • T0 is characterized by the identification of opportunities and approaches to health problems. 
  • T1 seeks to move basic discovery into a candidate health application. 
  • T2 assesses the value of application for health practice leading to the development of evidence-based guidelines. 
  • T3 attempts to move evidence-based guidelines into health practice, through delivery, dissemination, and diffusion research. 
  • T4 seeks to evaluate the “real world” health outcomes of population health practice.

adapted from Khoury MJ. et al. The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genomic discoveries into health care and disease prevention? Genet Med 2007:9(10):665-674.

slide7

ITHS Core and Program Structure

Administration: Portal and Program Incubator

Innovative Research and Research Partnerships

Pre-clinical Research Development Network

Biomedical Informatics

Community Outreach and Research Translation Core

Research

Resources

Clinical Research Center Network

Translational Technologies and Resources Core

Center for Biomedical Statistics

Regulatory Support and Bioethics Core

Education and Career Development

Short Courses

TL1

Tuition Support

KL2

Overarching Mentoring Programs

Funding Opportunities

Strategic Development and Evaluation

iths portal service
ITHS Portal Service

The Portal evaluates project goals and provides information about:

  • ITHS and institutional resources and services
  • Pilot and other funding opportunities
  • Educational programs/mentoring
  • Collaborations ( through membership database)
  • General questions about translational and clinical research
pre clinical research development network
Pre-Clinical Research Development Network
  • Highlights to date:
  • 2 types of Ignition Awards
    • Primate center (3)
    • Pharmacy (3)
  • Sponsored 7 MBA students
  • Supported 3 IND submissions
  • Supported 2 SBIR grant proposal submissions
  • Drug and Device Development Advisory Committee
  • ITHS/Coulter MBA summer fellowships
  • Ignition Awards
  • Academic Drug Development Symposium
slide11

Regulatory and Bioethics Support

  • Highlights to date:
  • Cross-institutional investigator clinical research training program
  • 8 junior investigators thru educational monitoring program
  • Completed the first year: ITHS Clinical Research Educational Series
  • Established a research coordinator core
  • Research bioethics consultation
  • Research bioethics collaboration and mentorship
  • Regulatory consultation visit program
  • Regulatory audit program
    • In place and available
  • Medical Monitoring and SAE reporting
    • In pilot phase but available
  • DSMB program
    • In development
study and data management
Study and Data Management
  • Highlights to date:
  • Launched the Center for Biomedical Statistics
  • Electronic tools for clinical trials management
  • Amalga collaboration with Microsoft
  • Toyota Lean: reduced nurse overtime by 50% (CRC), decreased wait time for appointments

Study data management tools

Computing and IT support for clinical and translational research

Accessing electronic medical record data

Evaluation support

Biomedical statistics

Research coordinator pool

research lab services
Research Lab Services
  • Highlights to date:
  • Created an institutional technology inventory with searchable web tool
  • Established WWAMI Practice Based Research Network
  • Piloted Data-Quest at key WWAMI practice sites
  • Speaker training workshop

Working in the Community

Conducting practice-based research

Building partnerships with American Indian/Alaska Native communities

NWABR: Request a speaker or get speaker training

Lab instrumentation and techniques

Scientific instrumentation data access

Bionutrition and body composition consultation

slide15

Small Pilot Project Grants

Twice yearly

10K, applications due Sept 28, 2009

Technology/Resource Access Grants

Three times a year

10K, applications due November 1, 2009

Ignition/Primate Center Award

Annually

100K, applications due February, 2010

ITHS Ignition/Pharmacy Award

Annually

20-40K, applications due in October, 2009

  • Highlights to date:
  • In first 16 months, ITHS awarded 60 grants for over $1M to investigators
  • representing 9 institutions
  • Funding level 20-35% depending on mechanism
  • Training program for grant review
  • Mentor program for those grants that miss funding
slide16

Education and

Training Programs

slide17

Degree and Certificate Programs

Predoctoral Multidisciplinary Clinical Research TL1 Training - offered as both a summer and a 12-24 month certificate-degree program.  

Postdoctoral Clinical Research Career Development KL2- multidisciplinary program, up to 5 years in length  

ITHS Tuition Support Fellowship - provides tuition support for MS or MPH degree in Epidemiology or Health Services from the School of Public Health and Community Medicine. 

slide18

Seminars and Short Courses

ITHS monthly Clinical Research Education Series - A seminar series for investigators and research staffthat features 23 clinical and translational research topics to be presented over two year cycle.

ITHS monthly Career Development Series for Scholars - A seminar series for scholars that features topics such as grant-writing, writing for publication, presenting at scientific meetings, and more.

ITHS monthly Technology Resources Seminar Series- A seminar series highlighting local research resources

Other ITHS Seminars, Training, and Short Courses - A broad array of training opportunities including the ITHS annual Boot Camp, Fundamentals of Clinical Trials, and more.

Educational Clearinghouse-Clinical and translational research training opportunities outside of ITHS, including certificate and degree programs, courses, training (, Good Clinical Practice, Human subject protection, etc.), workshops, and clinics offered by partners and other institutions.

clinical and translational research boot camp
Clinical and Translational Research Boot Camp

The ITHS Clinical and Translational Research Boot Camp

Basic training in clinical and translational research methods

Topics include: biostatistical concepts, clinical epidemiology and study design, ethical issues in research on human subjects, grantsmanship, randomized clinical trials, and regulatory issues.

The targeted audience is primarily incoming fellows and new faculty, other interested parties are welcome. 

Participants must be either an ITHS Member or Scholar to attend. 

Dates:  September 21 through 25, 2009Time:  9:00-11:50, 1:00-3:50 Monday-Friday (thirty 50-minute sessions)Location:  University of Washington, Magnuson Health Sciences Building, Room T733 Online Registration: Pending

All lectures will be streamed live on-line and archived to be made available later via the web as a benefit to ITHS members.For more information about the ITHS Clinical and Translational Research Boot Camp please send an email to shrtcrs@u.washington.edu or call (206) 616-5163.

tool kit at https www iths org research toolkit coordinator
Tool Kit at https://www.iths.org/research/toolkit/coordinator
translational technologies and resources core resources directory http www iths org resources
Translational Technologies and Resources CoreResources directory http://www.iths.org/resources
glossary of translational terms https www iths org glossary term 107
Glossary of translational termshttps://www.iths.org/glossary/term/107
iths membership
ITHS Membership
  • To reach our goals of promoting translational research requires collaboration between many groups: academia, industry, non-profit agencies, government, and the community. Any researcher or individual interested in translational research from any group is invited to become a member of the ITHS.
  • Currently have 754 members from the WWAMI region