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Nanocell. Intro of Drug Delivery System What is nanocell Marketing Ethics Mechanism Ms. Soraya Synthesis Ms. Titima In vivo In vitro Dr. Panthee Clinical trial Summary . Ms. Chanokkamon. Dr. Bonduush. Nanocell:. Introduction, Marketing part and Ethical issues.

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nanocell
Nanocell
  • Intro of Drug Delivery System
  • What is nanocell
  • Marketing
  • Ethics
  • Mechanism Ms. Soraya
  • Synthesis Ms. Titima
  • In vivo In vitro Dr. Panthee
  • Clinical trial
  • Summary

Ms. Chanokkamon

Dr. Bonduush

nanocell1

Nanocell:

Introduction, Marketing part

and Ethical issues

Ms Chanokkamon Cheawtada

Inter-U program AIT

scope marketing and ethics
Scope: Marketing and Ethics
  • Drug delivery system
    • General cancer
  • Liver cancer treatment
  • Conventional drug for treat liver cancer
  • Problems of conventional drug
  • What is “nanocell”?
  • Advantage of nanocell
  • Compare cost-benefit between conventional drug and nanocell
  • Using Calculation for profit cost for developing country (Ethics)
drug delivery system for cancer
Drug delivery system for cancer
  • Drug targeting of tumors
  • Maximize drug potency
  • Minimize systemic toxicity.
  • Drug carrier Route of administation
  • ●Liposome
  • composed of one or more phospholipid bilayer Intravenous(iv)injection
    • e.g. liposome entrapped doxorubicin
  • ●Bead
    • e.g. drug-eluting microspheres/beads Hepatic artery
    • (DEB) load with doxorubicin
  • ●Prodrug
    • e.g prodrug of cisplatin using dextran Intravenous(iv)injection
    • (galactose unit)
liver cancer treatment
Liver cancer treatment

Liver cancer

Localized unresectable

Localized resectable

Segmental resection -

Trisegmental resection

liver transplantation

Systemic chemotherapy

Tumor embolization

Chemoembolization

Hormone therapy

Radiolabeled

Recurrent

conventional drugs
Conventional drugs
  • .

Doxorubicin

IV injection

60-90 mg/m2- every 3 weeks

20-30 mg/m2/day - 3 days

every 3 to 4 weeks.

Dose depends upon which

regimen for cancer is being

Poor risk patient Reduce dosage

IV infusion

60-75 mg/m2

- every 3 weeks

From

http://asia.mims.com, http://www.rxmed.com

conventional drugs1
Conventional drugs

5-FU

IV injection

400 mg/m2

every 5 days

repeated every

4 weeks (28-day)

Oral

(capecitabine)

1250 mg/m2

twice daily 2 weeks

1 week rest

From

http://asia.mims.com, http://www.rxmed.com

conventional drugs2
Conventional drugs

Cisplatin

IV infusion

50-100 mg/m2

every 3-4 week

15-20 mg/m2

daily for 5 days/week

for 3-4 week.

From

http://asia.mims.com, http://www.rxmed.com

conventional drugs3
Conventional drugs

Combretastatin

IVinfusions

52 mg/m2

On day 1, 8, and 15.

courses repeat

every 28 days

From: http://www.jco.org

problem of conventional drug
Problem of conventional drug
  • Many side effect

- Drug effect on normal cell

e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea,

  • Less effective

- Drug cannot get into only liver but effect other organ

  • Too complicate in treatment

- For treat liver cancer use series of drug for more effectiveness

  • Series of drug

- take time for inject the drugs

- very painful because use large dose

  • Expensive
  • Drug resistance
nanocell2
Nanocell
  • Nanocell is small particle between 10-1000nm.

- less than 200 nm.

- Can pass through tumor blood vessels

- The outer shell anti-angiogenesis

- The inner core chemotherapy drugs.

- A "stealth" surface

- avoid immune system

slide14

From:http://www.medicalillustrator.com, http://www.3d4medical.com

advantages of nanocell
Advantages of Nanocell
  • Directly to the target site ( liver cancer)
  • Less side effect

- Not effect on normal cell

  • Not complicate for treatment

- Inject only one time in one cycle of treatment

  • More effective
  • Less invasive

- less pianful

- less injection time

  • Economic price
  • Easy to inject

- IV injection

compare cost benefit
Compare Cost-benefit

http://www.etonbio.com, http://www.hon.ch/News/HSN/527057.html,http://www.biotrend.com,https://www.sigmaaldrich.com, http://www.rocheusa.com

ethical issues
Ethical issues
  • Liver cancer population

- high incidence in Asia.

  • Almost countries in Asia are

- developing countries

  • Almost developing countries have

- a large number of poor people

e.g. Thai GDP per capita income 2,221 US$

  • “Nanocell for developing countries”

- economic price

nanocell for developing countries
Nanocell for developing countries

11,868 persons

1995 – 1997

Sriamporn, et al(2002)

summary
Summary
  • So nanocell has been made for solving those problems of the conventional drugs
  • For its price, there are two target groups

which are:

- the developing countries such as Thailand, Indonesia , it will be sold at whole sale

- the other countries at the retail.

addition
Addition

Body surface area in m2 =

√ { height (cm) x weight (kg) }/3600

= 1.845 m2

Standard WHO

wieght 70 kg

Hight 1.75 metre

(from Norgan 1994)