Assessing the WHO-recommended First-line ART regimens for Resource-limited settings: comparison of the relative virologicefficacy and resistance patterns of TDF/3TC/NVP to AZT/3TC/NVP in a RwandanCohort Jean-Claude Karasi M.D
Proportion of resistance mutations in patients with VL > 1000 copies/ml
Conclusions • In thiscohort, TDF/3TC/NVP was as effective as AZT/3TC/NVP but wasassociatedwithfewer discontinuations due to adverse effects. However, itwasless effective in patients withhighbaselineVL • What could be the optimal first line option for patients with high baseline viral load in resources limited settings where VL monitoring remains a challenge ?
ACKNOWLEDGMENTS • Institutional support • Rwanda Biomedical center • National refferalLaboratory • CRP-Santé • Lux-Development • Ministry of Heallth Rwanda