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Jean-Claude Karasi M.D

Jean-Claude Karasi M.D

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Jean-Claude Karasi M.D

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  1. Assessing the WHO-recommended First-line ART regimens for Resource-limited settings: comparison of the relative virologicefficacy and resistance patterns of TDF/3TC/NVP to AZT/3TC/NVP in a RwandanCohort Jean-Claude Karasi M.D

  2. Cohort description

  3. Results: Cohort baseline characteristics

  4. Proportion of patients attained the primary endpoint

  5. Proportion of resistance mutations in patients with VL > 1000 copies/ml

  6. Conclusions • In thiscohort, TDF/3TC/NVP was as effective as AZT/3TC/NVP but wasassociatedwithfewer discontinuations due to adverse effects. However, itwasless effective in patients withhighbaselineVL • What could be the optimal first line option for patients with high baseline viral load in resources limited settings where VL monitoring remains a challenge ?

  7. ACKNOWLEDGMENTS • Institutional support • Rwanda Biomedical center • National refferalLaboratory • CRP-Santé • Lux-Development • Ministry of Heallth Rwanda