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Fonction et Développement des Oligodendrocytes. B. Zalc CRICM, UPMC-Paris 6; Inserm U975; CNRS 7225 Hôpital de la Salpêtrière bernard.zalc@upmc.fr. 1. Généralités sur la myéline 2. Fonctions de la gaine de myéline 3. Origine des Oligodendrocytes 4. Migration des Oligodendrocytes

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slide1

Fonction et Développement des Oligodendrocytes

B. Zalc

CRICM, UPMC-Paris 6; Inserm U975; CNRS 7225

Hôpital de la Salpêtrière

bernard.zalc@upmc.fr

slide2

1. Généralités sur la myéline

2. Fonctions de la gaine de myéline

3. Origine des Oligodendrocytes

4. Migration des Oligodendrocytes

5. Développement des Oligodendrocytes

slide10

cm

rm

ri

Na+

- - - - - - - - - - - - - - - -

+ + +

+ + +

+ + +

+ + +

+ + +

+ + +

+ + +

+ + +

- - - - - - - - - - - - - - - -

Current can go forward axially

Or radially into the membrane

Increase radius

slide11

1

Unmyelinated

saltatory conduction

- - - -

- - - - - - - - - - - - - - - - -

+ + +

+ + +

- - - -

- - - - - - - - - - - - - - - - -

: Na channels

Saltatory conduction

+ + + + + + +

+ + + + + + +

+ + + + + + +

+ + + + + + +

Impulse jumps from

node to node

Latin: saltare = to jump

slide14

Myelinated

Unmyelinated

Myelination favoured if diameter > 1 micron

slide15

Contactin

Nfasc155

Nfasc186

4.1B

IIII-

Spectrin

AnkyrinB

Molecular organization of CNS nodes of Ranvier and paranodes

Glial Cell

Node

NrCAM

Paranode

Nav

Caspr

Contactin

Axon

IV spectrin

AnkyrinG

From Brophy, 2010

slide21

pD

pD

Pax6

Irx3

Irx3

Pax6

Oligodendrocytes

PDGFRa +

Motor

Neurons

p0

p0

p1

p1

p2

p2

Nkx2.2

Olig1/2

Olig1/2

pMN

pMN

p3

p3

Nkx2.2

V3

Dorsalizing factors (BMPs, Wnt, dorsalin…)

After E11.5

E8.5-E11.5

Ngn2

Nkx2.2

Ngn3

Ventralizing factor (Sonic hedgehog, …?)

Lu et al.,2000, Zhou et al., 2001, Zhou et al. 2002, Fu et al., 2002

slide22

late oligodendrocytes

~10-20% of the total

early oligodendrocytes

~70-80% of the total

The origin of oligodendrocytes in the rodent spinal cord

early oligodendrocytes

~10-20% of the total

N. Tekki-Kessaris

slide26

Spassky et al., J. Neurosci. 2002

Sema 3A

Sema 3F

Netrin-1

• Expression of receptors by OPCs

class 3 Sema

Neuropilin-1 and Neuropilin-2

/Sema 3A

/Sema 3F

DCC and Unc5h1

Netrin-1

(Embryonic)

(Post natal)

• Expression of factors in the context of the optic nerve

slide28

A2B5

GD3

NG2

Oligodendrocyte Precursor cell

Adult

Précursor

Oligodendrocyte Progenitor