Severe Acute Respiratory Syndrome (SARS). Presented by Parth Dave & Kuan-Mei Lin December 2, 2005 . Outbreaks. In November 2002, highly contagious and severe atypical pneumonia were observed in the Guangdong Province of southern China
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Presented by Parth Dave & Kuan-Mei Lin
December 2, 2005
Rota. P. et. al
Characteristic gene order of Typical coronaviruses and SARS:
5’-- Replicase (Rep)-- Spike (S)-- Envelope (E)-- Membrane (M)-- Nucleocapsid (N) –3’
Binds by using spike proteins. Enters either by membrane fusion or reseptor mediated endocytosis (clathrin pits)
(+) ssRNA used to create (-) ssRNA in cytoplasm
Has its own RNA poly
(-) strand forms replication complex attached to membrane
Complex produces new genomic RNAs and subgenomic mRNAs.
mRNAs code for N, M & S
Ribonucleoprotiens form from N + genomic RNA
Ribonucleoprotiens attach to S & M proteins at membrane
This complex comes detached into lumen (immature virion)
Mature as they progress through periphery of Golgi apparatus and becoming denser and more icosohedral.
Breathing difficulties 3-7 days from onset of symptoms
Sudden onset of high fever (>38°C) & dry cough
Wearing N95 mask was one of the main public preventive measures against SARS