The Mechanism of Protein Splicing:
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The Mechanism of Protein Splicing: * * * * the movie * * * * Animation by Maurice W. Southworth As seen in InBase, Francine Perler, Curator. SH. SH. O. CH 2. CH 2. C. NH. C. NH. Cys. Asn. Cys. O. N-extein. Intein. C- extein. SH. SH. O. CH 2. CH 2. C. NH. C. NH.

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Slide1 l.jpg

The Mechanism of Protein Splicing:

****the movie****

Animation by Maurice W. Southworth

As seen in InBase, Francine Perler, Curator


Slide2 l.jpg

SH

SH

O

CH2

CH2

C

NH

C

NH

Cys

Asn

Cys

O

N-extein

Intein

C-extein


Slide3 l.jpg

SH

SH

O

CH2

CH2

C

NH

C

NH

N-extein

Cys

Asn

Cys

O

Intein

C-extein


Slide4 l.jpg

SH

SH

O

CH2

CH2

C

NH

C

NH

N-extein

Cys

Asn

Cys

O

Intein

C-extein


Slide5 l.jpg

O

SH

SH

C

CH2

CH2

N-extein

C

NH

NH

Cys

Asn

Cys

O

Intein

C-extein


Slide6 l.jpg

O

SH

C

S

N-extein

CH2

CH2

C

NH

NH2

Cys

Asn

Cys

O

Intein

C-extein


Slide7 l.jpg

O

C

SH

S

N-extein

CH2

CH2

C

NH

NH2

Cys

Asn

Cys

O

Intein

C-extein


Slide8 l.jpg

O

SH

C

CH2

N-extein

S

CH2

NH

C-extein

C

NH2

Cys

Asn

O

Intein


Slide9 l.jpg

O

SH

C

CH2

N-extein

S

C-extein

CH2

NH

C

NH2

Cys

Asn

O

Intein


Slide10 l.jpg

O

SH

C

CH2

N-extein

S

C-extein

CH2

NH

C

NH2

Cys

Asn

O

Intein


Slide11 l.jpg

O

SH

CH2

C

N-extein

S

C-extein

CH2

NH

NH2

C

Cys

Asn

O

Intein


Slide12 l.jpg

SH

O

CH2

C

N-extein

S

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide13 l.jpg

O

SH

CH2

C

N-extein

S

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide14 l.jpg

O

C

S

CH2

N-extein

SH

C-extein

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide15 l.jpg

O

C

S

CH2

N-extein

SH

C-extein

CH2

NH

NH2

C

Cys

Asn

O

Intein


Slide16 l.jpg

O

C

S

CH2

N-extein

SH

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide17 l.jpg

O

C

S

N-extein

CH2

SH

C-extein

CH2

NH

NH2

C

Cys

Asn

O

Intein


Slide18 l.jpg

O

C

N-extein

S

CH2

SH

C-extein

CH2

NH

NH2

C

Cys

Asn

O

Intein


Slide19 l.jpg

O

C

N-extein

S

CH2

SH

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide20 l.jpg

O

C

N-extein

S

CH2

SH

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide21 l.jpg

O

C

N-extein

S

CH2

SH

C-extein

NH

CH2

NH2

C

Cys

Asn

O

Intein


Slide22 l.jpg

O

C

N-extein

S

CH2

NH2

SH

C-extein

C

O

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide23 l.jpg

O

C

N-extein

S

CH2

NH2

SH

C-extein

C

O

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide24 l.jpg

O

C

N-extein

S

CH2

NH2

SH

C-extein

C

O

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide25 l.jpg

O

C

N-extein

S

CH2

O

NH2

SH

C-extein

C

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide26 l.jpg

O

C

N-extein

S

CH2

O

NH2

SH

C-extein

C

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide27 l.jpg

O

C

N-extein

S

CH2

O

NH2

SH

C-extein

C

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide28 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH2

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide29 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH2

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide30 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH2

NH

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide31 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide32 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide33 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide34 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide35 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide36 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide37 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide38 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide39 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide40 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide41 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide42 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide43 l.jpg

O

C

N-extein

S

CH2

O

SH

C-extein

C

NH

NH2

CH2

CH2

C

NH2

O

Cys

Asn

Intein


Slide44 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide45 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide46 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide47 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide48 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide49 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide50 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide51 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide52 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide53 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide54 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide55 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide56 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide57 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide58 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide59 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide60 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide61 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide62 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide63 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide64 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide65 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide66 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide67 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide68 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide69 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide70 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide71 l.jpg

O

C

N-extein

S

CH2

O

C-extein

SH

C

NH2

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide72 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide73 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide74 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide75 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide76 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide77 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide78 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide79 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide80 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide81 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide82 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide83 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide84 l.jpg

O

C

N-extein

S

CH2

O

NH2

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide85 l.jpg

O

C

S

N-extein

CH2

NH2

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide86 l.jpg

O

C

S

N-extein

CH2

NH2

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide87 l.jpg

O

C

S

N-extein

CH2

NH2

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide88 l.jpg

O

C

S

N-extein

CH2

NH2

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide89 l.jpg

O

SH

C

N-extein

CH2

NH

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide90 l.jpg

O

SH

C

N-extein

CH2

NH

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide91 l.jpg

SH

O

CH2

C

N-extein

NH

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide92 l.jpg

SH

O

CH2

C

N-extein

NH

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide93 l.jpg

SH

O

CH2

C

N-extein

NH

O

Cys

C-extein

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide94 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide95 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide96 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide97 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide98 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide99 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide100 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


Slide101 l.jpg

SH

O

CH2

C

NH

N-extein

Cys

C-extein

O

SH

C

CH2

NH

CH2

C

NH2

Cys

Asn

O

Intein


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