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Population: 38.5 mln Reg. Blood Transf. Centers: 21 Donations: 1mln/year

NAT testing in Poland E. Brojer, M. Łętowska, A. Gronowska Institute of Hematology and Blood Transfusion, Warsaw, Poland. Introduction of NAT HCV in plasma for fractionation March 2000 HCV in all donations - Jan 2002. Population: 38.5 mln Reg. Blood Transf. Centers: 21

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Population: 38.5 mln Reg. Blood Transf. Centers: 21 Donations: 1mln/year

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  1. NAT testing in Poland E. Brojer, M. Łętowska, A. GronowskaInstitute of Hematology and Blood Transfusion, Warsaw, Poland • Introduction of NAT • HCV in plasma for fractionation March 2000 • HCV in all donations - Jan 2002 • Population: 38.5 mln • Reg. Blood Transf. Centers: 21 • Donations: 1mln/year

  2. LITHUANIA BALTIC SEA RUSSIA Gdańsk Słupsk Olsztyn Szczecin Białystok Bydgoszcz BELARUS Poznań GERMANY Warszawa Zielona Góra Łódź Kalisz Radom Lublin Wrocław Wałbrzych Kielce Opole Rzeszów Katowice Racibórz UKRAINE Kraków CZECH REP. SLOVAKIA NAT Test format • Cobas AmpliScreen Roche • plasma pools, 48 donations • 8 Labs in RBT Centers • TMA HIV/HCV Chiron • single donations • 2 Labs in RBT Centers HCVcoreAg used supplementarily, (mainly in emergency) • Reference Lab (IHBT, Warsaw) • certification for all NAT Laboratories

  3. Frequency of HCV positive „window period” donations • Plasma pool testing: 34/ 1.80 mln • HCVcore Ag: 10/ 0.34 mln • Single donation HIV/HCV : 0/ 0.39 mln Overall frequency 44/ 2.5 mln • Elevated ALT in 30% of HCV RNA positive donors

  4. Follow up and look back studies of HCV RNA positive/anti- HCV negative donors 29 23 16 Anti-HCV-/RNA HCV- 18 Anti-HCV-/RNA HCV+ 20 Anti-HCV+/RNA HCV+ 28 Anti-HCV+/RNA HCV- 25 4 27 8 21 33 17 6 12 11 22 13 5 14 7 6 5 4 3 2 1 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 • anti-HCV detected in all donors, observed for more than 3 months • HCV RNA was not detected in 2/35 (6 and 20 months after eroconversion) 3 31 0 RNAHCV(+) /anti-HCV (-) months

  5. HCV genotype frequency in HCV RNA(+)/antiHCV(-) blood donors (%)

  6. Viral load in HCV RNA positive/anti-HCV negative blood donors 4.2 x107 3.2x103

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