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中國醫藥大學競爭性團隊研究 中心 計畫

中國醫藥大學競爭性團隊研究 中心 計畫. 中文計畫名稱 : L5 醫學研究中心 英文計畫名稱 : L5 Medical Research Center. 整合型總計畫名稱： Identification of a Novel Cardiovascular Risk Factor through a Translational Approach. Director: 李源德 講座教授 Co-Director: Chu-Huang Chen ( 陳珠璜 ), MD PhD, Associate Professor, Baylor College of Medicine.

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中國醫藥大學競爭性團隊研究 中心 計畫

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  1. 中國醫藥大學競爭性團隊研究中心計畫 中文計畫名稱: L5醫學研究中心 英文計畫名稱: L5 Medical Research Center

  2. 整合型總計畫名稱： Identification of a Novel Cardiovascular Risk Factor through a Translational Approach • Director: 李源德講座教授 • Co-Director: Chu-Huang Chen (陳珠璜), MD PhD, Associate Professor, Baylor College of Medicine

  3. The composition of a new cardiovascular research center at CMU-CMUH: L5 Medical Research Center

  4. What is L5? • Electronegative LDL mildly oxidized in vivo. • L5 is the most highly electronegative LDL. • L5 can induce apoptosis of vascular endothelial cells. • Endothelial apoptosis contributes to atherosclerosis and thrombosis. LDL-C = 190 mg/dl LDL-C = 119 mg/dl

  5. L5 composition and its distinction from HDL Tang et al. ACC meeting in Chicago, April 1st 2008

  6. Metabolic Syndrome LDL-C all ranges Who has L5? Hypercholesterolemia LDL-C >160 mg/dL L5 Type 2 DM LDL-C all ranges Chronic Smokers LDL-C all ranges

  7. Interruption of the FGF2-PI3K-Akt Autoregulatory Loop by L5 Lu and Jiang et al. Diabetes 2008

  8. Internalization of L5 and oxLDL by LOX-1 and endocytosis of L1 by LDLR

  9. Role of LOX-1 in smoker L5 induced mitochondrial disruption Tang et al. ACC meeting in Chicago. April 1st 2008 Chen’s lab

  10. Effect of Zetia on L5 reduction in hamster fed with high-fat diet

  11. Morphological changes in EPC colonies with sustained exposure to L5 vs. L1

  12. Goal and significanceof the new cardiovascular research center • Goal • to establish an in vivo relevance of L5 in atherosclerosis. • Significance • Impact on public health in Taiwan • Impact on medical research in Taiwan

  13. Missions of the core laboratory and all divisions • Core Laboratory: (陳珠璜Assoc. Prof; 楊朝諭教授) 黃志揚教授 汪貴珍教授 張博淵助理教授 李安生助理教授 • will be providing L5 for cell and animal studies and performing all L5 analyses • fully characterize L5 and strengthen the theoretical basis for all the studies

  14. Division I—Cell Study Division (馬明琪教授; 李啟明副教授) 黃志揚教授, 李宗貴教授, 陳珠璜Assoc. Prof • to provide further evidence of L5’s capability of deranging the molecular homeostasis. • strengthen the theoretical basis for the animal and human studies • provide insights into new targets for treatment • 子計畫: • Effects of L5 on macrophage physiology • Effects of L5 on endothelium-dependent vascular functions • Effects of L5 on the expression of adhesion molecules in endothelial cells • Effects of L5 on hypertrophy and apoptosis in cardiomyocytes

  15. Division II—Animal Study Division: (汪貴珍教授, 郭薇雯副教授), 李安生助理教授, 陳珠璜Assoc. Prof • will be performing animal studies to establish the in vivo relevance of L5 in atherosclerosis. • to provide sufficient evidence to establish such a cause-effect relation. • 子計畫: • Induction of L5 synthesis in hamsters and investigation of the mechanism • Effects of L5 on EDR in aortic ring preparations • Role of L5 in diabetic cardiomyopathyin rat models

  16. Division III—Clinical Study Division: (張坤正副教授, 張博淵助理教授), 白培英醫師, 張詩聖醫師, 李源德講座教授, 陳珠璜Assoc. Prof • To establish clinical correlation between L5 and atherosclerosis • To provide human plasma samples for L5 isolation and purification at the core laboratory. • 子計畫: • L5 as a possible risk factor in CAD events • To test relationship of L5 with progress of atherosclerosis • To identify the specific modified lipids and/or proteins /peptides in L5 • To link to Pilot Clinical Trials with statin and Red rice

  17. Division IV—Imaging Study Division: (施庭芳教授, 何永仁主任), 沈戊忠教授, 李源德講座教授, 張坤正副教授, 陳珠璜Assoc. Prof • to provide direct visual evidence of vascular disease in humans • to establish a close correlation between L5 concentration and tissue perfusion in humans by using DCE-MRI technology • 子計畫: • Correlation between plasma L5 levels and pancreatic perfusion in humans

  18. Division V—Pilot Trial Study Division: (張永賢副校長, 陳清助主任), 汪貴珍教授, 郭薇雯副教授, 王宇澄醫師, 陳珠璜Assoc. Prof • to identify natural products as alternative regiments for L5 reduction in high risk patients, and • to examine whether L5 reduction is accompanied by clinical improvement of endothelial function. The two products to be tested are Monascus purpureus (紅麴) and garlic extract (大蒜). • 子計畫: • Effect of Monascus purpureus on L5 reduction in patients with T2DM • Effect of garlic on L5 reduction in patients with T2DM

  19. THANK YOU FOR YOUR ATTENTION!

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