What is the life expectancy of someone with Amyloidosis?

1. What is the life expectancy of someone with Amyloidosis? Amyloidosis is a group of diseases in which abnormal protein, known as amyloid fibril, builds up in tissue and organs. Amyloidosis is a serious health problem that can lead to life threatening organ failures. It is caused by changes in proteins, which make them insoluble. These amyloid proteins accumulate mainly in the tissue space between cells. Changes in proteins that makes them amyloid proteins occur because of gene mutation in DNA within cells. Life Expectancy As per the Genetic and Rare Diseases Information Center, on average people with hereditary ATTR amyloidosis live for 7 to 12 years after the diagnosis. And people with wild-type ATTR amyloidosis live an average of about 4 years after diagnosis according to the study published in the journal Circulation In addition, there are several factors that may affect survival rates and life expectancy in people with ATTR amyloidosis, including: The type of ATTR amyloidosis they have Which organs are affected When their symptoms began How early they began treatment Which treatments they receive Their overall health If anyone in your family/close relatives has been diagnosed with ATTR amyloidosis, I would highly recommend getting diagnosed as soon as possible. There is no known cure for ATTR amyloidosis. However, there are few treatments available in the market: liver transplant, it is used to treat some cases of familial ATTR amyloidosis Tegsedi® by AKCEA, an inotersen solution for subcutaneous injection for hATTR amyloidosis Stage 1 or 2 polyneuropathy adult patients. ATTR silencers, help to reduce the production of TTR in people with familial ATTR amyloidosis.

2. ATTR stabilizers may stop TTR from forming amyloid fibrils in people with familial or wild type ATTR amyloidosis. Your doctors may also recommend other treatments to help manage potential symptoms and complications of ATTR amyloidosis. However, early diagnosis and treatment may help slow the development of the disease, relieve symptoms, and improve your life expectancy.