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Ischemic Optic Neuropathy. Ophthalmology & Neuro-ophthalmology Dr. Omer Y. Bialer. Disclosure. No conflict of interests I have nothing to disclose ION = I schemic O ptic Neuropathy. Presentation’s outline. Introduction Terminology and Nosology

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ischemic optic neuropathy

Ischemic Optic Neuropathy

Ophthalmology & Neuro-ophthalmology

Dr. Omer Y. Bialer

disclosure
Disclosure
  • No conflict of interests
  • I have nothing to disclose

ION = Ischemic Optic Neuropathy

presentation s outline
Presentation’s outline
  • Introduction
  • Terminology and Nosology
  • Nonarteritic anterior ischemic optic neuropathy
  • Arteritic ION
  • Perioperative ION
  • Radiation optic neuropathy
  • “Take home massage” summary
introduction
Introduction
  • ION is the most common acute optic neuropathy > age 50
  • 2nd most common optic neuropathy after glaucoma
  • Relatively common neuro-ophthalmological disorder
  • Visual loss is often severe
  • No effective treatment or prevention
introduction1
Introduction
  • ION is due to:
    • poor blood flow to the optic nerve
    • Acute occlusion of the feeding arteries

Ophthalmic artery

Short posterior ciliary arteries

terminology nosology
Terminology & Nosology

ION

Nonarteritic ION (cardiovascular risk factors)

Arteritic ION

(vasculitis)

NonarteriticAnterior ION (NAION)

with swollen optic disc

NonarteriticPosterior ION (NA-PION) with normal optic disc

Arteritic Anterior ION (AAION)

with swollen optic disc

Arteritic Posterior ION (APION)

with normal optic disc

terminology nosology1
Terminology & Nosology

ION

Nonarteritic ION (cardiovascular risk factors)

Arteritic ION

(vasculitis)

NonarteriticAnterior ION (NAION)

with swollen optic disc

NonarteriticPosterior ION (NA-PION) with normal optic disc

Arteritic Anterior ION (AAION)

with swollen optic disc

Arteritic Posterior ION (APION)

with normal optic disc

GCA

Other vasculitides

Idiopathic ION

Perioperative ION

Radiation optic neuropathy

naion
NAION

(Nonarteritic Anterior Ischemic Optic Neuropathy)

naion is the most common ion
NAION is the most common ION
  • ~ 90% of ION
  • Incidence: 1 / 10,000 / year (> 50 y.o)

0.5/ 100,000 / year (overall)

  • Mean age at onset 57-65
  • Presentation: acute painless monocular

visual field loss ± visual acuity loss

the most important risk factor is a crowded optic disc
The most important risk factor is a crowded optic disc
  • “disc at risk” =

small optic disc + minimal cup

crowded

normal

glaucoma

more risk factors for naion
More risk factorsfor NAION
  • Hypertension (50%)
  • Diabetes mellitus (25%)
  • Obstructive sleep apnea (55%)
  • Hyperlipidemia
  • Ischemic heart disease
  • Obesity
  • Tobacco use
  • High intraocular pressure
several meds are associated with naion
Several meds are associated with NAION
  • Erectile dysfunction drugs
  • Amiodarone
  • Vasoconstrictors
  • Cocaine

(e.g. Viagra, Cialis)

(e.g. nasal decongestants)

the pathogenesis of naion differs from ihd or cva
The pathogenesis of NAION differs from IHD or CVA

Edema of optic disc

Cardiovascular risk factors

decrease in blood flow

Compression of axons and blood vessels

Crowded optic disc

Blockage of axonal flow

Necrosis and demyelination of nerve fibers

eye exam
Eye Exam
  • visual acuity & color vision can be normal
  • A relative afferent pupillary defect
  • Normal anterior segment
  • Optic disc edema
  • Crowded optic disc

(fellow eye)

Peripapillary hemorrhages

Obscured borders

Nerve fiber layer edema

the most common visual field defect is a superior or inferior scotoma
The most common visual field defect is a superior or inferior scotoma

Combined superior & inferior defect

Inferior altitudinal defect

Superior arcuate defect

naion is a clinical diagnosis
NAION is a clinical diagnosis
  • Elderly patient +/- cardiovascular risk factors
  • Acute painless optic neuropathy

+ disc edema

+ crowded optic disc in fellow eye

  • Rule out arteritic AION
  • Do Humphrey visual fields
  • Imaging is not in indicated
  • Frequent follow-up
there is no proven treatment for naion
There is no proven treatment for NAION
  • IONDT = ION decompression trial
    • A multicenter randomized controlled clinical trial
    • no efficacy for optic nerve fenestration
  • Intravitreal steroids (triamcinolone acetate)
  • Intravenous noradrenaline
  • Warfarin
  • TPA
  • Levodopa + carbidopa
there is no proven treatment for naion1
There is no proven treatment for NAION
  • Oral prednisone 40-60mg daily –

may hasten resolution of disc edema

  • Some evidence for anti-VEGF

intravitrealinjections

p rophylaxis
Prophylaxis
  • Control of cardio-vascular risk factors
  • Aspirin 100 mg daily – limited evidence

for second eye prophylaxis

disc edema resolves in 1 month
Disc edema resolves in 1 month

cup

Optic atrophy with cupping

Optic atrophy

significant improvement is rare
Significant improvement is rare
  • ~40% experience partial improvement
  • Improvement may take up to 6 months
  • 15% risk for fellow eye involvement in 2 years
  • < 5 % recurrent AION (the same eye)
  • A significant visual field defect persists
arteritic ion
Arteritic ION

And Giant Cell Arteritis (GCA)

50 of arteritic ion are d t giant cell arteritis
>50% of Arteritic ION are d/t Giant Cell Arteritis
  • Other etiologies include:
    • Systemic Lupus Erythematosus
    • Wegener’s granulomatosis
    • Behcet’s disease
    • Churg Strauss
    • PolyarteritisNodosa
gca key facts
GCA* - key facts
  • Large vessel vasculitis
  • Predilection for the aortic arch
  • Incidence 20 / 100,000 / year (> age 50)
  • 20% of GCA patients experience severe visual loss
  • AION is the most common ophthalmic manifestation of GCA
  • A-AION is an ophthalmic emergency !

* GCA = Giant Cell Arteritis (Temporal arteritis)

arteritic ion presents like any ion but
Arteritic ION presents like any ION, but . . .
  • 75% have typical systemic symptoms
  • 30% have preceding transient visual loss
  • 54% have visual acuity of count-fingers  No light perception
  • >50% second eye ION within hours -weeks

(“amaurosisfugax”)

(vs 26% in NAION)

there are specific funduscopic findings
There are specific funduscopic findings

The involved swollen optic disc is acutely pale

NAION

there are specific funduscopic findings1
There are specific funduscopic findings

Ischemic retina

Cherry red spot

Branch Retinal Artery Occlusion

Central Retinal Artery Occlusion

there are specific funduscopic findings2
There are specific funduscopic findings

Lack of choroidal perfusion

normal choroid

Choroidalhypoperfusion indicates multifocal ischemia on Fluorescein angiography

the workup of suspected arteritic ion
The workup of suspected Arteritic ION

GCA Symptoms / signs ?

Do blood tests but

yes

no

ESR, CRP, Hb, PLT, Fibrinogen

IV Solomedrol Prednisone + aspirin

until biopsy results

Iv Solomedrol Prednisone + aspirin

NAION

high

normal

Urgent TAB*

TAB* in 1 w

* TAB = Temporal Artery Biopsy

ophthalmic gca should be treated with iv steroids
“Ophthalmic GCA” should be treated with IV steroids
  • Few studies evaluated treatment protocols
  • Studies in ophthalmology differ from rheumatology
  • We recommend:
    • IV methylprednisolone 1000mg/d for 3 days
    • followed by a very slow taper of oral prednisone
    • Aspirin 100mg daily
    • Rheumatology consultation & follow-up
perioperative ion
Perioperative ION

(post operative AION and PION)

ion is a rare surgical complication
ION is a rare surgical complication
  • ION is an uncommon but devastating complication after various types of surgeries
    • Intraocular surgeries
    • Intraocular injections
    • Non-ocular surgeries
  • ION may also occur after:
    • renal dialysis
    • cardiac catheterization

d/t Elevated intraocular pressure

ion may complicate non ocular surgeries
ION may complicate non-ocular surgeries
  • The 2 most “classic” are :
    • CABG
    • Spinal surgery
  • Commonly bilateral
  • There is often profound visual loss
  • Visual loss may be immediate or delayed (days)

(mostly AION, 0.06%)

(mostly PION, 0.2%)

the differential diagnosis of post operative visual loss includes
The differential diagnosis of post-operative visual loss includes
  • Ischemic optic neuropathy
  • Retinal artery occlusion
  • Angle closure glaucoma

Cherry red spot

Hazy cornea

Unresponsive mid-dilated pupil

Red “angry” eye

the differential diagnosis of post operative visual loss includes1
The differential diagnosis of post-operative visual loss includes
  • Cortical blindness
  • Corneal erosion

Bilateral occipital stroke

Epithelial

irregularity

there is no prospective controlled data regarding perioperative ion
There is no prospective / controlled data regarding perioperative ION
  • Risk factors:
    • Obesity
    • Male gender
    • Prolonged surgical time
    • Surgery in the prone position
    • Large fluid shifts / severe blood loss
there is no effective treatment
There is no effective treatment
  • Prognosis is poor – significant improvement in minority of patients
  • Should correct anemia, saturation & hypotension to improve perfusion
  • No evidence for efficacy of :
    • Aspirin
    • Anti - coagulants
    • Thrombolytics
    • Anti-glaucoma drops
slide38
RON

(Radiation Optic Neuropathy)

ron is a late complication
RON is a late complication
  • Prevalence ~ 0.5%
  • Mean interval 18 months
  • The optic nerves must be in the radiation field
  • (range: 3 months – 9 years)
the risk factors are
The risk factors are:
  • Radiation dosage
  • Age
  • Diabetes mellitus
  • Presence of compressive optic neuropathy
  • Concomitant chemotherapy
  • Previous radiotherapy
  • Multiple sclerosis
  • (>total 50 Gy or single dose > 10 Gy)
ron mostly presents as pion
RON mostly presents as PION
  • May be monocular or binocular
  • 45% have visual acuity of no light perception
  • Diagnosis is one of exclusion:
    • Suspected Optic neuropathy
    • PMH of radiotherapy
    • No other obvious explanation
    • Optic nerve enhancement on MRI
isolated enhancement on mri
Isolated enhancement on MRI

optic nerve enhancement

T1W with fat suppression + gadolinium

there are few treatment options
There are few treatment options
  • Oral corticosteroids (prednisone 1mg/kg)
  • Anticoagulants (heparin)
  • Aspirin
  • Hyperbaric oxygen (30-60min/day x 14-30 days)
  • Intravenous Bevacizumab (2-4 cycles every 2 weeks)
suspected ron
Suspected RON ?

Onset < 48-72 hours ?

yes

no

VEP

Look for other etiologies

Brain+orbits MRI with gadolinium

normal

abnormal

Hyperbaric oxygen

yes

PO prednisone

Enhancement ?

Consider IV Bevacizumab

Other optic neuropathy

prognosis of ron is poor
Prognosis of RON is poor
  • Spontaneous recovery is rare
  • Treatment is mostly ineffective
  • 85% visual acuity ≤ 20/200
  • Optic atrophy appear in 6-8 weeks
  • Enhancement on MRI resolves after several months
conclusions
Conclusions

(the “take home massage”)

ion is an ophthalmic emergency
ION is an ophthalmic emergency
  • Patients with GCA+ION are in danger of catastrophic, irreversible, bilateral blindness that may be prevented by prompt treatment with corticosteroids
  • Any patient > 50 presenting with ION 

an immediate workup to rule out GCA

ion is not another type of cva
ION is not “another type of CVA”
  • Although considered a “stroke of the optic nerve” and shares many risk factors with cerebrovascular disease,

It cannot be directly compared to cerebral

infarction, and therefore the evaluation should not

be similar to that of cerebral infarction.

there is no effective treatment for ion
There is no effective treatment for ION
  • there are no class I studies showing benefit from any medical or surgical treatments

TPA

Steroids

Anti VEGF

Heparin

Aspirin

Levodopa

Erythropoietin

Decompression surgery

Noradrenalin

Hyperbaric oxygen

limited efficacy for prophylaxis
Limited efficacy for prophylaxis
  • Aspirin 100mg daily
  • Control of cardiovascular risk factors
  • suspect GCA !!!
  • Avoid prolonged surgical time and dramatic shifts in body perfusion during surgrey
  • Consider routine serial brain MRIs after brain radiotherapy to detect RON early
thank you
Thank you

For listening

acknowledgments
Acknowledgments
  • Based on the chapter:

Optic nerve: Ischemic.

Bialer OY, Bruce BB, Biousse V, Newman NJ.

Oxford textbook in Neuro-ophthalmology

Oxford textbook in clinical neurology

Editor: Bremner F.

Publisher: Oxford University Press

  • Gratitude to : Dr. Karin Mimoni

Dr. HadasKalish-Stiebel

Dr. Beau B. Bruce

Dr. Nancy J. Newman

Dr. ValérieBiousse

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