260 likes | 373 Views
Case Presentation. Ali Razi Urologist Tehran Medical University 2012. Clinical Picture. 81 y old male Acute Urinary retention. PMH : TUR-P 4y ago , BPH on pathologic report and one time urethral dilatation after that . Appendectomy 3 y ago.
E N D
Case Presentation Ali Razi Urologist Tehran Medical University 2012
Clinical Picture • 81 y old male • Acute Urinary retention. • PMH : • TUR-P 4y ago , BPH on pathologic report and one time urethral dilatation after that . • Appendectomy 3 y ago. • DM : Controlled by oral antiglycemic agents .
Lt. kidney : NL • Rt. Kidney : Mild Hydronephrosis + 5 cm simple cyst . • Bladder : a 4*4*5 cm solid mass on Rt. Lat. Side.
On Cystoscopy , there is a ulcerated , sessile mass on the Rt. Lat. Side of bladder. • Bimanual exam before the TUR the bladder was not fixed but there is palpable pelvic mass with suspicion of extravesical extension. • TUR-Bx was done .
Pathologic Report High Grade Transitional Cell Carcinoma + Deep muscle involvement
CBC : Mild Anemia • LFT : NL. • Serum electrolytes and Ca : In Nl. Range • CXR : Unremarkable • Whole Body Bone Scan : No evidence of Metastasis
Further Discussion Options ?
First Option : Radical Cystectomy
Second Option Bimodality Treatment
Neoadjuvant chemotherapy + Radical Cystectomy + Adjuvant Chemotherapy
Third Option Three modality Treatment
Chemotherapy + Radiation + TUR-BT
Debates 1 • Resections : • Male : bladder- Prevesical fat-Prostate – Seminal Vesicles-Prostatic urethra • Modifications : Prostate Sparing _ Seminal Vesicle Sparing • Female : Ant. Pelvic Exentration : bladder- Prevesical fat-Uterine – Ant. Vaginal wall- Ovaries-Urethra • Modification : Uterine Sparing _ Ovarian sparing – Urethral Sparing Lymph node Dissection : • Number of lymph nodes • Lymph node density ( LND) : • Conventional Vs. Extended pelvic lymph node dissection
Debates 2 Contraindications for cystectomy • Unrespectable lymph node involvement • Fixed bladder to pelvic wall • Rectosigmoid involvement Frozen Section for end of ureter Prostatic urethral involvement