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Scientific Issues in Placebo Use: Understanding Different Placebo Responses and Indicators for Major Depression

This presentation by Dr. Jun Ishigooka explores the scientific aspects of placebo use in the treatment of major depression. It discusses the law of initial value, different placebo responses in a single disorder, and indicators for melancholia. The talk also delves into the main effect and alternative interaction models, as well as the use of surrogate endpoints and rating scales for symptoms.

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Scientific Issues in Placebo Use: Understanding Different Placebo Responses and Indicators for Major Depression

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Presentation Transcript

  1. How Scientific Is placebo Use? Jun Ishigooka, MD, PhD Department of Psychiatry, Kitasato University School of Medicine Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  2. Scientific Issues in Placebo Use • “the Law of Initial Value” • Different Placebo Responses in a Single Disorder Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  3. Scientific Issues in Placebo Use • “the Law of Initial Value” Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  4. Conventional • Main Effect Model b. Alternative Interaction Model (Fisher S et al, 1965) Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  5. Panic Disorder (1) (Uhlenhuth EH et al, 1997) Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  6. Panic Disorder (2) (Uhlenhuth EH et al, 1997) Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  7. Panic Disorder (3) (Uhlenhuth EH et al, 1997) Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  8. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  9. Rating Scales for Symptoms ---Manner of Drug / Placebo Response??? ---Surrogate Endpoint Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  10. Scientific Issues in Placebo 2. Different Placebo Responses in a Single Disorder Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  11. Placebo Responses in Antidepressants Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  12. Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  13. Indicators for Melancholia Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

  14. Major Depression Jun Ishigooka_the 3rd Kitasato-Harvard Symposium

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