Unraveling the Mystery of DnaA and Its Impact on DNA Structure

Jun 26, 2025

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This research delves into how DnaA directly affects DNA by melting the duplex structure. The study by Duderstadt et al. sheds light on this crucial interaction, offering insights into genetic processes. Understanding these mechanisms opens new avenues in genetics and molecular biology research.

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dna structure
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Unraveling the Mystery of DnaA and Its Impact on DNA Structure

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DnaA directly melts duplex DNA. KE Duderstadt et al. Nature000, 1-5 (2011) doi:10.1038/nature10455

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DnaA engages ssDNA in a manner similar to RecA. KE Duderstadt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10455.

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KE Duderstadt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10455

DnaA extends ssDNA in solution. KE Duderstadt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10455.

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KE Duderstadt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10455

The ATPase pore of assembled DnaA binds ssDNA. KE Duderstadt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10455.

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A Guse et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10379

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Architecture of the MecA–ClpC molecular machine. F Wang et al. Nature 000 , 1 - 5 (2011) doi:10.1038/nature09780.

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