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ClustalW Alignment of L-Proteins from Various HBVs Infections Highlighting Cysteine Residues

This supplementary figure presents a detailed alignment of L-proteins from HBVs that infect a diverse range of animal species. The sequence alignment was performed using ClustalW version 1.83, prominently highlighting cysteine residues in red. The alignment includes human, gibbon, chimpanzee, orangutan, woolly monkey, woodchuck, and ground squirrel sequences, showing conserved regions and variations across the different species. This comparative analysis is essential for understanding functional and structural aspects of viral proteins and potential implications for cross-species infection.

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ClustalW Alignment of L-Proteins from Various HBVs Infections Highlighting Cysteine Residues

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  1. Supplementary Figure 1. Alignement by Clustalw 1.83 of L proteins from HBVs infecting a wide range of animals. Cysteine residues are highlighted in red. preS1 D12980-HUMAN MGGWSSKPRQG-------------MGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD---FNPNKDH-WP--DGIKVGAGDFGPGFTPPHGGLLGWSPQAQGIL---TTVPAA------- M12906-HUMAN MGGWSSKPRQG-------------MGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD---FNPNKDH-WP--EAIKVGAGDFGPGFTPPHGGLLGWSPQAQGIL---TTVPAA------- AAL84829-GIBBON ------------------------MGQNHSVTNPLGFFPDHQLDPLFRANSNNPDWD---FNPNKDN-WP--DATKVGVGAFGPGFTPPHGGLLGWSPQAQGIL---TTLPAA------- AAG4196-CHIMPANZEE ------------------------MGQNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPNKDN-WP--DANKVGAGAFGPGLTPPHGGLLGWSPQAQGIL---TTLPIN------- BAB12583-CHIMPANZEE MGQQLSWTIPLE------------WGKNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPNKDN-WP--TANEVGAGAFGPGLTPPHGGLLGWSPQAQGKL---ITMPAN------- D00220-HUMAN ------------------------MGQNLSTSNPLGFFPEHQLDPAFKANTNNPDWD---FNPKKDY-WP--EATKVGAGAFGPGFTPPHGGLLGLSPQAQGIL---TTLPAN------- X77309-HUMAN ------------------------MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWD---FNPNKDT-WP--DANKVGAGAFGLGFTPPHGGLLGWSPQAQGIL---QTLPAN------- M32138-HUMAN ------------------------MGQNLSTSNPLGFFPDHQLDPAFRANTANPDWD---FNPNKDS-WP--DANKVGAGAFGLGFTPPHGGLLGWSPQAQGIL---QTLPAN------- AF193864-ORANG-UTAN ------------------------MGQNLSVSNPLGFFPEHQLDPLFRANTNNPDWD---FNPNKDT-WP--EATKVGVGAFGPGFTPPHGGLLGWSPQAQGVT---TILPAV------- AF193863-ORANG-UTAN ------------------------MGQNLSVTNPLGFFPEHQLDPLFRANTNNPDWD---FNPNKDT-WP--EATKVGVGAFGPGFTPPHGGLLGWSPQAQGVT---TILPAV------- AA07456-WOLLY MONKEY ------------------------MGLNQSTFNPLGFFPSHQLDPLFKANAGSADWD---KNPNKDP-WP--QAHDTAVGAFGPGLVPPHGGLLGWSSQAQGLS---VTVPDT------- 86062931-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKFSLVSRDPPPKPYINQSAQTFEIKPGPIIVPGIRDIPRGL 8918452-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKFSLVSRDPPPKPYINQSAQTFEIKPGPIIVPGIRDIPRGL 88101359-WOODCHUCK MGNNIKVTFNPDKIAAWWPAVGTYYT-TTYPQNQSVFQPGIYQTTSLINPKNQQELDSVLINRYKQIDWNTWQGFPVDQKLPLVSRDPPLKPHINQSAQTFEIKPGPIIVPGIRDIPRGL 84267998-GROUND-SQUIRREL MGNNIKVTFDPNKLAAWWPTVGTYYTPTTTVTNPAIFKPGIYQTTSLKNPKNQQELDAILMTRYKEIDWDNWQGFPVNQRLPVSNNNPPS----GQRAETFEIKSRPIIVPGIRDIPRGI D12980-HUMAN -PPPASTNRQSGRQPTPISPPLRDSHPQ-AMQWNST---TFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTASPISSIFSRTGDPA--PNMESTTSGFLGPLLVLQAGFFLLTRILTIPQ M12906-HUMAN -PPPVSTNRQSGRQPTPISPPLRDSHPQ-AMQWNST---TFHQALLDPRVRGLYFPAGGSSSGTVNPVPTTVSPISSIFSRTGDPA--PNMESTTSGFLGPLLVLQAGFFLLTRILTIPQ AAL84829-GIBBON -PPPASTNRQSGRQATPISPPLRDTHPQ-AMQWNST---VFHQTLQDPRVRGLYFPAGGSSSGTVNPAPTTASHISSIFSRTGDPA--PNMDNITSGFLGPLLVLQAGFFLLTKILTIPQ AAG4196-CHIMPANZEE -PPPASTNRQSGRQPTPHSPPMRDTHPQ-AMHWNST---TFHQALQDPRVRGLYFPVGGSSSGTVNPVLNTASHISSIFSRTGDPA--PNMETITSGFLGPLLVLQAGFFLLTKILTIPQ BAB12583-CHIMPANZEE -PPPASNKRQSGRQPTPLSPPLRETHPQ-AMHWNTT---TFHQDL-----------AGGSSSGTVSPVPNTVSHISSIFSRTGDPA--PNMESITSGFLGPLLVLQAVFFLLTKILTIPQ D00220-HUMAN -PPPASTNRQSGRQPTPLSPPLRDTHPQ-AMQWNST---TFHQALQDPRVRGLYFPAGGSSSGTLNPVPNTASHISSVFSTTGDPA--PNMENITSGFLGPLLVLQAGFFLLTKILTIPQ X77309-HUMAN -PPPASTNRQSGRQPTPLSPPLRNTHPQ-AMQWNST---TFHQTLQDPRVRGLYFPAGGSSSGTVNPVLTTASPLSSIFSRIGDPA--LNMENITSGFLGPLLVLQAGFFLLTRILTIPQ M32138-HUMAN -PPPASTNRQSGRQPTPLSPPLRNTHPQ-AMQWNST---TFHQTLQDPRVRGLYLPAGGSSSGTVNPVPTTVSPISSIFSRIGDPA--LNMENITSGFLGPLLVLQAGFFLLTKILTIPK AF193864-ORANG-UTAN -PPPASTNRQSGRQPTPISPPLRDTHPQ-AMQWNST---VFHQTLQDPRVRGLYFPAGGSSSGTVSPVPTSASPISSIFLKTGDPA--PNMENISSGFLGPLLVLQAGFFLLTKILTIPQ AF193863-ORANG-UTAN -PPPASTNRQSGRRPTPISPPLRDTHPQ-AMQWNST---VFHQALQDPRVRGLYFPAGGSSSGTVSPVPTTASPISSTFLKTGDPA--LNMESISSGFLGPLLVLQAGFFLLTKILTIPQ AA07456-WOLLY MONKEY -PPPPSTNRDKGRKPTPATPPLRDTHPQ-AMTWNTS---SFQSYLQNPKVRGLYFPAGGSTSSIVNPVPTTASTTSSSFSTTGVPV--STMDITSSGFLGPLLALQAVFFLLTKILTMPQ 86062931-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFHLQGFVDGLRDLTTTERQHNAYRDPFTTLSPAVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 8918452-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFHLQGFVDGLRDLTTTERQHNAYGDPFTTLSPAVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 88101359-WOODCHUCK VPPQTPTNRDQGRKPTPPTPPLRDTHPHLTMKNQTFRLQGFVDGLRDLTTTERYHNAYGDPFTTLSPVVPTVSTILSPPSTTGDPALSPEMSP--SSLLGLLAGLQVVYFLWTKILTIAQ 84267998-GROUND-SQUIRREL VPPQTPSNRDQRRKPTPLTPPLRDTHPHLTMKNQTGHLQGFAEGLRALTTSDHHNSAYGDPFTTLSPVVPTVSTTLSPPLTIGDPVLSTEMSP--SGLLGLLAGLQVVYFLWTKILTIAQ preS2 HBsAg

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