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Fundamentals of Powder Compression. attractive forces exist between particles van der Waal’s, H-bonding, electrostatic consider a number of granules in a die to which a force is applied. Compression. consider the force transmitted through the powder bed

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fundamentals of powder compression
Fundamentals of Powder Compression
  • attractive forces exist between particles
    • van der Waal’s, H-bonding,

electrostatic

consider a number of granules in

a die to which a force is applied

CHEE 440

compression
Compression
  • consider the force transmitted through the powder bed
    • descending upper punch, stationary lower punch

CHEE 440

force volume relationships
Force-Volume relationships
  • at the end of the compression stage the initial porosity has been decreased
    • need some porosity for disintegration therefore need relation between force applied (FA) and porosity (e)

CHEE 440

heckel plots
Heckel Plots

CHEE 440

influence on bioavailability
Influence on Bioavailability
  • compression force affects disintegration time of tablet

CHEE 440