1 / 14

10, 000

10, 000. 10, 000 DNA lesions X 1 trillion cells 10,000,000,000,000,000. DNA damage leads to mutations. DNA damage leads to mutations. 1) toxic chemicals (industrial & environmental). 2) X-rays (clinic). 5) UV rays (sun). 3) viruses (HPV). 4) oxidation (respiration, smoking).

adena-hampton
Download Presentation

10, 000

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 10, 000 OEIT Star BioChem (LA and KMV)

  2. 10, 000 DNA lesionsX 1 trillion cells10,000,000,000,000,000 OEIT Star BioChem (LA and KMV)

  3. DNA damage leads to mutations OEIT Star BioChem (LA and KMV)

  4. DNA damage leads to mutations 1) toxic chemicals (industrial & environmental) 2) X-rays (clinic) 5) UV rays (sun) 3) viruses (HPV) 4) oxidation (respiration, smoking) OEIT Star BioChem (LA and KMV)

  5. DNA damage leads to mutations toxic chemicals (industrial & environmental) X-rays (clinic) mutations disease UV rays (sun) viruses (HPV) oxidation (respiration, radiation, smoking) OEIT Star BioChem (LA and KMV)

  6. Oxidation can cause mutations in DNA OEIT Star BioChem (LA and KMV)

  7. Oxidation can cause mutations in DNA OEIT Star BioChem (LA and KMV)

  8. Oxidation can cause mutations in DNA OEIT Star BioChem (LA and KMV)

  9. DNA glycosylase proteins help repair DNA damage caused by oxidation DNA glycosylases OEIT Star BioChem (LA and KMV)

  10. Today’s activity: explore DNA glycosylases with Star BioChem (You can find it online too!) human hOGG1 (37 °C) archeabacteria Pa-AGOG (100 °C!) OEIT Star BioChem (LA and KMV)

  11. Proteins perform many important biological functions hemoglobin carry oxygen in the blood F1 ATPase generate energy antibody protect against infections microtubules cell division aquaporin water transport OEIT Star BioChem (LA and KMV) Protein Data Bank website

  12. The function of a protein is determined by its structure structure function OEIT Star BioChem (LA and KMV)

  13. These two proteins both fix the same DNA defect. human hOGG1 archeabacteria Pa-AGOG Protein Evolution: Proteins with similar functions tend to have similar 3D structures. 2) Proteins with similar 3D structures DO NOT ALWAYS have exactly the same amino acid sequence. The folding is important for function. OEIT Star BioChem (LA and KMV)

  14. Hydrophobic YELLOW (Polar) Hydrophilic GREEN Acid RED Base BLUE Amino Acids Identify the amino group, the acid group, andthe side chains. The side chains are also called “R groups” (R = residues) OEIT Star BioChem (LA and KMV)

More Related