ISGO International Conference on Structural Genomics Looking back to the committee’s earlier report … Berlin, 10-13 October 2002 Task force on tracking and registration of targets Report of Structural Genomics Task Force on Target Tracking Steve Bryant Steve Brenner Yo Matsuo John Moult
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Looking back to the committee’s earlier report …
Berlin, 10-13 October 2002
Task force on tracking and registration of targets
April 4-6, 2001, Airlie House
Structural Genomics Laboratories shall adopt a policy of open exchange of target information …
… to facilitate target selection and avoid unnecessary duplication of effort
… to demonstrate international cooperation in the structural genomics effort
Data exchange shall be by the simplest possible method …
… each laboratory shall maintain a public ftp site listing target sequences and the status of experimental work
… in a simple standardized format to be finalized by a working group the Airlie House meeting
Information content …
… laboratory-assigned target name
… laboratory name
… date of most recent update
… target sequence
… status-of-work code
Status-of-work code examples …
… in PDB
… work stopped
Three options were considered …
… a “deluxe” central registry
… a “bare bones” central registry
… a decentralized registry, where each laboratory independently maintains a list of targets under investigation
The need for a central target registry should be considered again in future …
… laboratories may evaluate the registry to be developed by John Norvell for the NIH-funded centers
… if this proves to be more efficient means of data exchange, an international repository should be created in future
Does the “bare bones” central target registry achieve its goals ?
… to avoid duplication
… to demonstrate cooperation
Should additional information be included in the central target registry ?
… target synonyms ?
… target classification ?
… other suggested targets ?