ISGO International Conference on Structural Genomics Looking back to the committee’s earlier report … Berlin, 10-13 October 2002 Task force on tracking and registration of targets Report of Structural Genomics Task Force on Target Tracking Steve Bryant Steve Brenner Yo Matsuo John Moult
Looking back to the committee’s earlier report …
Berlin, 10-13 October 2002
Task force on tracking and registration of targets
April 4-6, 2001, Airlie House
Structural Genomics Laboratories shall adopt a policy of open exchange of target information …
… to facilitate target selection and avoid unnecessary duplication of effort
… to demonstrate international cooperation in the structural genomics effort
Data exchange shall be by the simplest possible method …
… each laboratory shall maintain a public ftp site listing target sequences and the status of experimental work
… in a simple standardized format to be finalized by a working group the Airlie House meeting
Information content …
… laboratory-assigned target name
… laboratory name
… date of most recent update
… target sequence
… status-of-work code
Status-of-work code examples …
… in PDB
… work stopped
Three options were considered …
… a “deluxe” central registry
… a “bare bones” central registry
… a decentralized registry, where each laboratory independently maintains a list of targets under investigation
The need for a central target registry should be considered again in future …
… laboratories may evaluate the registry to be developed by John Norvell for the NIH-funded centers
… if this proves to be more efficient means of data exchange, an international repository should be created in future
Does the “bare bones” central target registry achieve its goals ?
… to avoid duplication
… to demonstrate cooperation
Should additional information be included in the central target registry ?
… target synonyms ?
… target classification ?
… other suggested targets ?