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ISGO International Conference on Structural Genomics Looking back to the committee’s earlier report … Berlin, 10-13 October 2002 Task force on tracking and registration of targets Report of Structural Genomics Task Force on Target Tracking Steve Bryant Steve Brenner Yo Matsuo John Moult

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isgo international conference on structural genomics
ISGO International Conference on Structural Genomics

Looking back to the committee’s earlier report …

Berlin, 10-13 October 2002

Task force on tracking and registration of targets

report of structural genomics task force on target tracking
Report of Structural Genomics Task Force on Target Tracking

Steve Bryant

Steve Brenner

Yo Matsuo

John Moult

Janet Thornton

April 4-6, 2001, Airlie House

airlie house recommendations
Airlie House Recommendations ...

Structural Genomics Laboratories shall adopt a policy of open exchange of target information …

… to facilitate target selection and avoid unnecessary duplication of effort

… to demonstrate international cooperation in the structural genomics effort

airlie house recommendations4
Airlie House Recommendations ...

Data exchange shall be by the simplest possible method …

… each laboratory shall maintain a public ftp site listing target sequences and the status of experimental work

… in a simple standardized format to be finalized by a working group the Airlie House meeting

summary of discussion on target data exchange format
Summary of discussion on target data-exchange format

Information content …

… laboratory-assigned target name

… laboratory name

… date of most recent update

… target sequence

… status-of-work code

summary of discussion on target data exchange format6
Summary of discussion on target data-exchange format

Status-of-work code examples …

… cloned

… purified

… crystallized

… in PDB

… work stopped

summary of discussion on target data exchange mechanisms
Summary of discussion on target data-exchange mechanisms

Three options were considered …

… a “deluxe” central registry

… a “bare bones” central registry

… a decentralized registry, where each laboratory independently maintains a list of targets under investigation

airlie house recommendations13
Airlie House Recommendations ...

The need for a central target registry should be considered again in future …

… laboratories may evaluate the registry to be developed by John Norvell for the NIH-funded centers

… if this proves to be more efficient means of data exchange, an international repository should be created in future

now that this has been done questions for discussion today
Now that this has been done, questions for discussion today ...

Does the “bare bones” central target registry achieve its goals ?

… to avoid duplication

… to demonstrate cooperation

Should additional information be included in the central target registry ?

… target synonyms ?

… target classification ?

… other suggested targets ?