Echemi Chemical N-Boc-1-aminocyclobutanecarboxylic acid Basic Attributes

1. CAS No:120728-10-1 Formula:C10H17NO4 Synonyms:N-BOC-1-AMINOCYCLOBUTANE ACID;1-AMINOCYCLOBUTYL-1-CARBOXYLIC PROTECTED;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC CARBOXYLIC ACID;1-(TERT-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID;1-TERT-BUTOXYCARBONYLAMINO-CYCLOBUTANECARBOXYLIC ACID;1-(T-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID;BOC-AC4C-OH China Export:From 2018.11 to 2019.11, N-Boc-1-aminocyclobutanecarboxylic acid from China was 76,865,630KG while total export value was $825,816,556. The biggest proportion of exporting volume in the last 12 months was 14.24% in 2019.05. CARBOXYLIC N-BOC ACID, ACID;1-N-BOC-AMINO-CYCLOBUTANE total export volume of Echemi Chemical N-Boc-1-aminocyclobutanecarboxylic acid Basic Attributes CAS No：120728-10-1 Molecular Formula ：C10H17NO4 Molecular Mass ：215.25 Exact Mass ：215.115753 PSA ：75.6 A^2 LogP ：1.2 InChIKeys ：ROVVUKFHORPDSM-UHFFFAOYSA-N H-bond Acceptor ：4 H-bond Donor ：2 SP3 ：0.80 RBN ：4 Echemi Chemical N-Boc-1-aminocyclobutanecarboxylic acid Characteristics Appearance ：White to light brown Powder Density ：1.18±0.1 g/cm3(Predicted) Melting Point ：129-133 °C(lit.) Bolling Point ：362.1±21.0 °C(Predicted)

2. Flash Point ：172.8±22.1 °C Refractive Index ：1.500 Storage Condition ：2-8°C Echemi Chemical N-Boc-1-aminocyclobutanecarboxylic acid Safety Information Hazard Class ：IRRITANT HS Code ：29242990 UN No. ：NONH for all modes of transport WGK_Germany ：3 Risk Code ：22 Safety Instructions ：36 Dangerous Mark ：Xn P Code ：P305 + P351 + P338 Hazard Statements ：H302-H319 Echemi Chemical N-Boc-1-aminocyclobutanecarboxylic acid Production Methods To a stirred solution of 1-aminocyclobutane-1-carboxylic acid (2 g, 17 mmol) in 1, 4- dioxane: HTo

3. a stirred solution of 1-aminocyclobutane-l-carboxylic acid (30 g, 139.53 mmol, 1.0 eq) in 1, 4-dioxane (300 ml) at 0 °C was added 2N NaOH solution (300 ml) followed by (Boc)Stage 1. 1 -[(tert-Butoxycarbonyl)am ino]cyclobutanecarboxyl ic acid To a solution of 1-amino-1-cyclobutane carboxylic acid (2.92 g, 25.4 mmol), NaOH (3.04 g, 76.2 mmol), THF (100 mL) and water (100 mL) at RT was added d-tert-buty dcarbonate (8.30 g, 38.1 rnmoD and the reaction was strred for 24 hrs, The reacUon mixture was acdfled to pH5 usng 2M HC and the mixture was extracted w[th EtOAc (2x 200 mL). The cornbned organcs were dried over MgSO4, ifitered and concentrated in vacuo to give the tWe compound as a whfte sod (1.05 g, 19percent). LCMS: m/z 238 [M+Hj.Intermediate 68 1-({[(1, 1-dimethylethyl)oxy]carbonyl}amino)cyclobutanecarboxylic acid [0684] [0685] To a solution of 1-aminocyclobutanecarboxylic acid (626 mg, 5.44 mmol) in 5.6 ml of 1 M aqueous sodium hydroxide and 4 ml of methanol was added Boc-anhydride (1.425 g, 6.53 mmol) at 0° C. The reaction mixture was warmed to room temperature and stirred for 12 hours. After most of the methanol was evaporated, the solution was acidified to pH 2 with 1 M HCl and extracted with ethyl acetate. The organic extracts were combined and washed with brine. Evaporation of the solvent afforded the title compound (1.09 g). [0686] Reference Example F-2