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Clinical Evidence

Clinical Evidence. Professional Continuous Glucose Monitoring. Severe Hypoglycemic Events. Per Patient Year. Before CGMS. After CGMS. Leads to a Reduction in Severe Hypoglycemic Events. 10 patients with a history of severe hypoglycemia CGMS profiles reviewed and therapy adjustments made

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Clinical Evidence

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  1. Clinical Evidence Professional Continuous Glucose Monitoring

  2. Severe Hypoglycemic Events Per Patient Year Before CGMS After CGMS Leads to a Reduction in Severe Hypoglycemic Events • 10 patients with a history of severe hypoglycemia • CGMS profiles reviewed and therapy adjustments made • No Change in HbA1c (7.2 +/- 0.8) • No Change in total daily insulin dose Sabbah et al., Diabetes, 2001 50 (suppl. 2):1877-PO.

  3. 1st Use 2nd Use Number of hypoglycemicevents per 72 hrs Decreases Hypoglycemic Events in Type 1 Pediatric Patients • 27 Type 1 Pediatric Patients (6–13 yrs), with a mean HbA1c of 7.6% on MDI therapy • CGMS profiles reviewed and therapy adjustments made • Hypoglycemic Events Reduced • Hypoglycemia defined at 55 mg/dl Adapted from Schiaffini et al., Diabetes Metab Res Rev 2002; 18:324-9.

  4. 12.8 6.7 Reduces A1C While Improving Hypoglycemia Detection CGMS • 12 Pediatric Type 1 Patients randomized into fingerstick group or CGMS group • Both groups received intensive treatment • Therapy adjustments were made as required Fingerstick 12.0% 6.7% % A1C Change Average # of Hypo Events Detected per Patient Chase et al., Pediatrics 2001, 107:222-26.

  5. > 300 mg/dL 214–300 mg/dL 181–240 mg/dL Reveals Postprandial Hyperglycemia Previously Hidden With Fingersticks % of peak post meal glucose levels over the target level of 180 mg/dL • 56 Type 1 Pediatric patients with HbA1c 7.7% and near target pre-meal glucose • 90% experienced glucose levels of > 180 mg/dl after meals • Almost 50% experienced glucose levels of > 300 mg/dl after meals Normal A1C and Target Ranges May Not be Enough Overall Glycemic Control Boland E, et al. Diabetes Care 2001;24:1858-1862.

  6. Change in Bolus/Rapid-acting Insulin Change in Basal/Intermediate or Long-acting Insulin Change in Correction Algorithm Change in treatment of Hypoglycemia Nighttime Change Due to Dawn Phenomenon Modification of Regimen for High Fat Meals Modification of Regimen for High Glycemic Foods Referral for Counseling to Improve Adherence with Diabetes Regimen Alteration in the Approach to Exercise Determines Bolus / Basal Therapy Modification • 35 Type 1 Pediatric patients with poor compliance • Investigators were surprised by the number of therapy modifications • 50% inappropriately managed hypoglycemia • 30% did not re-check SMBG post-hypoglycemia Percent Therapy Modification Adapted from Kaufman F et al; Diabetes Care 2001; 24(12): 2030-2034.

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