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Frank Forkl (ME) 15 April 2009

Midterm Project Status Update P10054 – Ex Vivo Rodent Lung Deposition System / Cigarette Smoking Machine. Frank Forkl (ME) 15 April 2009. Project Status Updates. P10054 – Ex Vivo Rodent Lung Deposition System / Cigarette Smoking Machine Project Family Bioengineering Track

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Frank Forkl (ME) 15 April 2009

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  1. Midterm Project Status UpdateP10054 – Ex Vivo Rodent Lung Deposition System/ Cigarette Smoking Machine Frank Forkl (ME) 15 April 2009

  2. Project Status Updates P10054 – Ex Vivo Rodent Lung Deposition System / Cigarette Smoking Machine • Project Family • Bioengineering • Track • Biomedical Systems and Technologies • Start Term • 2009-1 (planned start of MSD I) • End Term • 2009-2 (planned end of MS II) • Faculty Guide • Dr. Risa Robinson (ME) Confirmed Faculty Guide • Technical Support Advisor • Mr. Ed Hanzlik (ME) • Primary Customer • Dr. Risa Robinson (Mechanical Engineering) • American Cancer Society (Unconfirmed) • Secondary Customer • Dr. Kathleen Lamkin-Kennard (Mechanical Engineering)

  3. Project Mission Statement – Ex Vivo Rat Lung • Product Description • Modular system • Produce an aerosol of fluorescent particles • Particles pass into excised rodent lungs inside a pressure controlled chamber • Simulates breathing inside the rodent. • Concentration /flow rate measured on entrance and exit • Lungs will then be sectioned and analyzed to compare against deposition models for more specific spatial distributions • Project Deliverables / Business Goals • System to verify particle deposition models in lungs • Applications in medical research • Pharmaceuticals • Smoking / Cancer Research

  4. Project Mission Statement – Ex Vivo Rat Lung • Primary Market • American Cancer Society / Cancer Research • Pharmaceutical Researchers • Stakeholders • Cancer and other Researchers • Pharmaceutical companies • Users of Inhaled Medications • Patients of Inhalant-caused diseases

  5. Current Status– Ex Vivo Rat Lung • This project does not have a Phase 2. No enhancements to stated goals are envisioned • It is possible that a conceptually similar system could be developed for other deposition studies • Current state of P09054 - behind schedule • Remaining work (if any) would be appropriate for a Co-op/Grad student • Not adequate work level to justify full 5-10 member Senior Design team • Funding for project only secured through 31 December 2009 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  6. Project Mission Statement – Cigarette Smoking Machine • Product Description • Artificial device to simulate smoking of a cigarette • Reproduce accurate cigarette smoking behavior • Collect data on substances deposited in lungs • Provide a physical test to compare CFD model against • Project Deliverables / Business Goals • Allow for a more realistic picture of substances inhaled by a smoker • Reduce flaws in testing procedure that Tobacco companies have been exploiting • Primary Market • American Cancer Society / Cancer Research • Stakeholders • Cancer and other Researchers • Smokers • Second-Hand Smoke Victims • Cigarette Companies and Retailers

  7. Current Status– P08042Cigarette Smokine Machine • System does not deliver published values of poly aromatic hydrocarbons (nanograms / milligrams) • Barrier to accomplishment of aims of ACS funded research • Staffing: Currently co-op working on project, another lined up for 084 • Goals of project at this Stage • Collecting data on four parameters based on varying inputs • Milligrams of tar/particles/PAH on 44mm Cambridge filter • ng/mg of collected PAH • Particle deposition in plastic lung cast • Size distribution of particles • CFD modeling of lung deposition correlation • Funding for this project more likely to be secured than P10054 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  8. Goals of Cigarette Smoking Machine • More accurately simulate behavior of smokers • Reduce flaws in testing procedure that Tobacco companies have been exploiting • Collect smoker “profiles” experimentally • Use software like LabView to use these profiles to operate machine based on profiles • Correlate experimentally collected data against CFD models *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  9. Goals of Cigarette Smoking Machine Long-Term • Replicating smokers behavior real-time in data collection • Puff-by-Puff Analysis – Measure carcinogens in each individual puff • Grow actual lung cells in cast to collect more realistic deposition data • Move further into Bioengineering realm • Use P09054 data to improve P10042 *Meetings with Ed Hanzlik 3/27/09, Ed Hanzlik and Dr. Risa Robinson 4/1/09

  10. Objective Tree

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  12. House Of Quality

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