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Case Study on Human Papillomavirus. Teresa Dominguez LaTasha Hardy Francisca Mata. Case Study Overview. 25-five-year-old carpenter. Several hyperkeratotic papules (warts) on Palm inside of index finger. Do not change size. Cause only minimal discomfort.

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Case Study on



Teresa Dominguez

LaTasha Hardy

Francisca Mata

Case Study Overview

  • 25-five-year-old carpenter

  • Several hyperkeratotic papules (warts) on

  • Palm inside of index finger

  • Do not change size

  • Cause only minimal discomfort

  • Spontaneously disappear after a year

What are Warts?

Non-cancerous skin growths in the epidermis

Caused mostly by HPV-1, 2 and 4

Usually skin-colored and feel rough to the


Several types:

Common warts

Foot (planar) warts

Flat warts

Fig. 1 HPV infecting the


Fig. 2 More extreme case of

common warts.

Question I

Will this virus infection spread to

other body parts?

Transmission via contact

Infection of basal cells of epidermis

Breach in the skin predisposing factor

There is a possibility of spreading warts to other parts of your body through breaks in the skin.

Question II

After its disappearance, is the infection

likely to be completely resolved

or persist in the host?

Immunocompetent persons:

Once infected with a specific HPV type,

it is unlikely

Immunosuppressed persons:

Can present with numerous treatment

resistant warts

Recurrent infections with same HPV type

Question IIIWhat viral, cellular, and host conditions regulate the replication of this virus and other HPV’s?

  • The Virus

    • icosahedral particle, 72 capsomers

    • Closed, circular dsDNA

computer colorized EM image of Papillomavirus capsid

Genomic organization of HPV-16

Dna replication
DNA Replication

  • Replicates and assembles in the nucleus

  • Dependent on:

    • transcription is tightly regulated by the differentiation state of the infected epithelial cell

Qiv how would the papilloma type causing this infection be identified
QIV:How would the papilloma type causing this infection be identified?

What is known

Detection methods
Detection Methods

  • Clinical Recognition

  • PCR and RT-PCR

  • PCR Cloning and Sequencing

  • Standard enzyme linked immunosorbent assay (ELISA)

  • Histological Analysis

Qv is it likely that this type of hpv is associated with human cancer
QV: Is it likely that this type of HPV is associated with human cancer?

This type of HPV is not associated with human cancer

HPV-2 (hand warts)

Common skin wart

Does not cause genital warts

Not associated with development of cancer

15 classified as “high-risk”

HPV Strains:

  • 16,18,31,33,35,39,45,51,52,56,58,59,68,73, &82

  • 16 & 18 cause 70% of cervical cancers

  • 2 types of cervical cancer (squamous cell cancer and adenocarcinoma)

HPV and Cancer

  • Anal cancer, vulvar cancer, penile cancer, and throat cancer

  • 3 classified as probable high-risk (HPV-26,53, &66)

  • 12 classified as “low-risk” (HPV-6,11,40,42,43,44,54,61,70,72,81, &CP6108)

Hpv induced cancers
HPV- Induced Cancers



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