Guidelines in the Management of RA. Haya M. Al- Malaq Lecturer, Clinical Pharmacy Dept. Clinical Pharmacist Rheumatology Haya_malak@yahoo.com. Introduction .
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Haya M. Al-Malaq
Lecturer, Clinical Pharmacy Dept.
Clinical Pharmacist Rheumatology
The ACR has defined the following criteria (>4) for the classification of RA:
earlier age at disease onset, high titer of RF, elevated ESR, and swelling of 20 joints .
Glucocorticoids. Low-dose oral glucocorticoids(10 mg of prednisone daily, or the equivalent) and local injections of glucocorticoids are highly effective for relieving symptoms in patients with active RA.
These guidelines are drawn from a synthesis of expert opinion, a survey of rheumatologists, published guidelines, and, whenever possible, data on toxicity.
Toxicity may range from mild to serious and from reversible to irreversible.
To prevent renal toxicity in patients who are at risk:
The major risk factor for retinal toxicity appears to be the combination of:
Hematologic toxicities of SSZ:
Patient's risk factors for steroid AE: